【摘要】：目的對(duì)不同嚴(yán)重程度的阻塞型睡眠呼吸暫停綜合征(obstructive sleep apnea syndrome,OSAS)患者進(jìn)行橫斷面研究,分析不同嚴(yán)重程度的OSAS患者肝酶水平的變化情況及特點(diǎn),并結(jié)合其血脂代謝情況,探討OSAS引起肝損害的可能機(jī)制。方法本研究共納入本院2015年1~12月收治的98例OSAS患者,將其中睡眠呼吸暫停低通氣指數(shù)(apnea hypopnea index,AHI)≥15(中重度)者納入研究組,AHI15(輕度和正常)者納入對(duì)照組。比較兩組患者肝酶水平變化及其血脂代謝情況,并對(duì)肝酶水平變化與OSAS嚴(yán)重程度進(jìn)行相關(guān)性分析。結(jié)果研究組患者體重指數(shù)(body mass index,BMI)和腰圍均大于對(duì)照組(P0.05),夜間最低血氧濃度明顯低于對(duì)照組(P=0.005)。研究組患者谷草轉(zhuǎn)氨酶(aspartate aminotransferase,AST)、乳酸脫氫酶(lactate dehydrogenase,LDH)、甘油三酯(triglyceride,TG)水平以及AST/谷丙轉(zhuǎn)氨酶(alanine aminotransferase,ALT)比值均明顯高于對(duì)照組(P0.05)。校正BMI和性別的影響后,AHI與AST水平具有一定相關(guān)性(r=0.442,P=0.035)。結(jié)論隨著OSAS嚴(yán)重程度的增加,AST水平呈升高趨勢(shì),AST/ALT1可以作為診斷早期肝損害的參考指標(biāo),而OSAS患者TG水平升高和缺氧是造成肝損害的重要因素。
[Abstract]:Objective to study the changes and characteristics of hepatic enzymes in patients with obstructive sleep apnea syndrome (obstructive sleep apnea syndrome,OSAS) with different severity, and to analyze the metabolic status of serum lipid in the patients with different severity of Sleep Apnea Syndrome (OSAS). To explore the possible mechanism of liver damage induced by OSAS. Methods from January to December 2015, 98 patients with OSAS were enrolled in this study. Sleep apnea hypopnea index (apnea hypopnea index,AHI) 鈮，

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