【摘要】：對(duì)比敏感度是衡量人眼在不同空間明暗對(duì)比下分辨物像的能力，反映人眼識(shí)別空間復(fù)雜物體的能力。對(duì)比敏感度由空間頻率通道進(jìn)行調(diào)諧，空間頻率通道調(diào)諧曲線的包絡(luò)構(gòu)成對(duì)比敏感度函數(shù)。對(duì)比敏感度作為弱視診斷和療效評(píng)價(jià)的手段之一，已在臨床和科學(xué)研究中得到廣泛應(yīng)用。研究弱視眼與正常眼對(duì)比敏感度的差異對(duì)理解弱視的病理機(jī)制及其診療具有十分重要的意義。 本文通過對(duì)174例正常兒童眼和100例兒童弱視眼的對(duì)比敏感度數(shù)據(jù)進(jìn)行分析，正常眼與弱視眼對(duì)比敏感度存在差異，此差異進(jìn)一步通過“對(duì)比敏感度-空間頻率通道”模型，得到正常眼和弱視眼的空間頻率通道數(shù)目相同，并計(jì)算通道帶寬。為了確保推導(dǎo)出的空間頻率通道及其帶寬的有效性，，另取獨(dú)立的48例兒童弱視眼的對(duì)比敏感度數(shù)據(jù)進(jìn)行交叉驗(yàn)證。從空間頻率通道探討弱視眼和正常眼的對(duì)比敏感度存在差異的原因。 本文的主要工作如下： 1、首先闡述對(duì)比敏感度研究的重要性，綜述了國(guó)內(nèi)外取得的研究成果和研究現(xiàn)狀，在此基礎(chǔ)上提出本文的研究目的和研究?jī)?nèi)容。 2、借助OPTEC6500視功能測(cè)試儀，采用心理物理學(xué)方法，設(shè)計(jì)了對(duì)比敏感度檢測(cè)的實(shí)驗(yàn)方案。 3、在浙江大學(xué)醫(yī)學(xué)院附屬第二醫(yī)院醫(yī)院眼科中心，對(duì)174例正常兒童眼和148例兒童弱視眼進(jìn)行眼科檢查，詳細(xì)記錄每例受試者的視功能檢查數(shù)據(jù)。 4、對(duì)采集到的174例正常眼和100例弱視眼的對(duì)比敏感度數(shù)據(jù)進(jìn)行統(tǒng)計(jì)分析。通過對(duì)比敏感度-空間頻率通道模型，PCA和Promax旋轉(zhuǎn)推導(dǎo)弱視眼和正常眼的空間頻率通道的調(diào)諧曲線，利用半高寬法計(jì)算通道帶寬�？臻g頻率通道的有效性采用獨(dú)立的48例弱視眼對(duì)比敏感度數(shù)據(jù)進(jìn)行交叉驗(yàn)證。通過分析弱視眼和正常眼空間頻率通道數(shù)目及帶寬的異同，探討兒童弱視眼對(duì)比敏感度缺損的原因。 數(shù)據(jù)分析結(jié)果表明：空間頻率為1.5～18.0c/deg時(shí)，弱視眼和正常眼均存在3個(gè)空間頻率通道；空間頻率峰值為3.0、6.0、12.0c/deg時(shí)，正常眼的通道帶寬分別為：1.04、1.03、0.98octaves，弱視眼的通道帶寬分別為：1.04、1.02、0.75octaves，表明弱視眼在中、高空間頻率的通道帶寬比正常眼小，由此推測(cè)弱視眼對(duì)比敏感度的缺損由對(duì)應(yīng)空間頻率通道帶寬的減小引起。
[Abstract]:Contrast sensitivity is a measure of the ability of human eyes to distinguish objects under different spatial contrast, reflecting the ability of human eyes to recognize complex objects in space. Contrast sensitivity is tuned by spatial frequency channel, and the envelope of tuning curve of spatial frequency channel constitutes contrast sensitivity function. As one of the methods of amblyopia diagnosis and evaluation, contrast sensitivity has been widely used in clinical and scientific research. It is very important to study the difference of contrast sensitivity between amblyopia and normal eyes in understanding the pathological mechanism and diagnosis and treatment of amblyopia. The contrast sensitivity data of 174 normal children and 100 children with amblyopia were analyzed. The contrast sensitivity of normal eyes and amblyopia eyes was different. The number of spatial frequency channels in normal eyes and amblyopic eyes was the same, and the channel bandwidth was calculated. In order to ensure the validity of the derived spatial frequency channels and their bandwidth, the contrast sensitivity data of 48 children with amblyopia were cross-validated. To explore the causes of difference in contrast sensitivity between amblyopia and normal eyes from spatial frequency channels. The main work of this paper is as follows: 1. Firstly, the importance of contrast sensitivity research is expounded, and the research results and research status at home and abroad are summarized. On the basis of this, the purpose and content of this paper are put forward. 2. With the help of OPTEC6500 visual function tester and psychophysical method, the experimental scheme of contrast sensitivity testing is designed. 3. In the ophthalmology center of the second affiliated Hospital of Zhejiang University Medical College, 174 normal children's eyes and 148 children's amblyopic eyes were examined by ophthalmology. The visual function examination data of each subject were recorded in detail. 4. The contrast sensitivity data of 174 normal eyes and 100 amblyopia eyes were statistically analyzed. The tuning curves of the spatial frequency channels of amblyopia and normal eyes were derived by contrast sensitivity spatial frequency channel model PCA and Promax rotation. The bandwidth of the channel was calculated by using the half height width method. The validity of spatial frequency channels was cross-validated by 48 independent contrast sensitivity data of amblyopic eyes. By analyzing the similarities and differences of spatial frequency channels and bandwidth between amblyopia and normal eyes, the causes of contrast sensitivity defect in amblyopic eyes were discussed. The results of data analysis showed that there were three spatial frequency channels in amblyopia and normal eyes when the spatial frequency was 1.5~18.0c/deg. When the spatial frequency peak value was 3.0 ~ 6.0 ~ 12.0c/ deg, the channel bandwidth of normal eyes was 1.04v 1.03v 0.98octaves. the channel bandwidth of amblyopic eyes was 1.041.02 鹵0.75octaves. it indicated that amblyopic eyes were in amblyopia. The channel bandwidth of high spatial frequency is smaller than that of normal eye, so the defect of contrast sensitivity of amblyopia is caused by the decrease of channel bandwidth of corresponding spatial frequency.
【學(xué)位授予單位】：浙江工業(yè)大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2012
【分類號(hào)】：R777.44

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