【摘要】：目的研究血清chemerin在輕中度阻塞性睡眠呼吸暫停低通氣綜合征(OSAHS)患者中水平變化、影響因素及意義。方法選取經(jīng)多導(dǎo)睡眠圖(PSG)監(jiān)測(cè)新診斷的病例組(包括輕度OSAHS組28例、中度OSAHS組23例)、對(duì)照組(體檢健康者)30例。記錄睡眠呼吸暫停低通氣指數(shù)(AHI)、最低脈搏氧飽和度(LSpO_2),測(cè)定體質(zhì)指數(shù)(BMI)、空腹血糖(FPG)及血清chemerin水平。結(jié)果輕度OSAHS組血清chemerin、降鈣素原(PCT)水平均顯著高于對(duì)照組(P0.05);中度OSAHS組chemerin水平顯著高于輕度組(P0.05)。簡(jiǎn)單線性相關(guān)提示:chemerin與BMI、FPG、AHI呈正相關(guān)(分別r=0.272、0.820、0.837,均P0.05),與LSp O2呈負(fù)相關(guān)(r=-0.702,P0.05);多重線性相關(guān)分析提示AHI、BMI是血清chemerin的影響因素。結(jié)論 chemerin或可作為OSAHS病情嚴(yán)重程度的全新評(píng)價(jià)指標(biāo)。
[Abstract]:Objective to study the changes of serum chemerin levels in patients with mild to moderate obstructive sleep apnea hypopnea syndrome (OSAHS). Methods the newly diagnosed cases (28 cases of mild OSAHS group, 23 cases of moderate OSAHS group) and 30 cases of control group (healthy persons) were selected by polysomnography (PSG) monitoring. The minimum pulse oxygen saturation (LSpO_2) of sleep apnea hypopnea index (AHI), fasting blood glucose (FPG) of body mass index (BMI),) and serum chemerin were measured. Results Serum chemerin, procalcitonin (PCT) levels in mild OSAHS group were significantly higher than those in control group (P0.05), and chemerin level in moderate OSAHS group was significantly higher than that in mild OSAHS group (P0.05). Simple linear correlation suggested that chemerin was positively correlated with BMI,FPG,AHI (r = 0.272U 0.820, 0.837, respectively, P0.05), and negatively correlated with LSp O2 (r = 0.702, P 0.05). Multiple linear correlation analysis suggested that AHI,BMI was an influential factor of serum chemerin. Conclusion chemerin may be a new index for evaluating the severity of OSAHS.
【作者單位】： 解放軍第401醫(yī)院干部一科;
【分類號(hào)】：R766

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本文編號(hào)：2376358