【摘要】：目的:探討羧甲基纖維素鈉眼液聯(lián)合重組人表皮生長因子(recombinant human epidermal growth factor,rh EGF)對白內(nèi)障患者超聲乳化術(shù)后干眼的治療效果。方法:選取2015-10/2016-05于我院接受治療的白內(nèi)障超聲乳化術(shù)后干眼癥患者150例150眼,隨機分為試驗組(75例75眼)和對照組(75例75眼)。試驗組采用羧甲基纖維素鈉眼液聯(lián)合rh EGF治療,對照組采用羧甲基纖維素鈉眼液單藥治療。記錄患者治療前及治療后1wk,1mo的干眼主觀癥狀評分、角膜熒光素染色(FL)情況、淚液分泌試驗(SⅠt)以及淚膜破裂時間(BUT)。結(jié)果:治療前,兩組患者的干眼主觀癥狀、淚膜穩(wěn)定性指標(biāo)(BUT、FL、SⅠt)比較差異無統(tǒng)計學(xué)意義(P0.05)。治療后,兩組患者隨時間延長各指標(biāo)均有明顯改善,差異有統(tǒng)計學(xué)意義(P0.01),試驗組較對照組干眼主觀癥狀更輕,差異有統(tǒng)計學(xué)意義(P0.05)、BUT明顯延長,差異有統(tǒng)計學(xué)意義(P0.05)、FL明顯減少,差異有統(tǒng)計學(xué)意義(P0.05)、SⅠt明顯增加,差異有統(tǒng)計學(xué)意義(P0.05)。結(jié)論:羧甲基纖維素鈉眼液聯(lián)合rh EGF可有效改善白內(nèi)障術(shù)后干眼癥狀,恢復(fù)淚膜穩(wěn)定性,其療效顯著優(yōu)于單獨使用羧甲基纖維素鈉眼液。
[Abstract]:Objective: to investigate the therapeutic effect of carboxymethylcellulose sodium eye fluid combined with recombinant human epidermal growth factor (recombinant human epidermal growth factor,rh EGF) on dry eyes after phacoemulsification in cataract patients. Methods: 150 patients (150 eyes) with dry eye after phacoemulsification were randomly divided into trial group (75 cases, 75 eyes) and control group (75 cases, 75 eyes). The experimental group was treated with carboxymethyl cellulose sodium eye liquid combined with rh EGF, while the control group was treated with carboxymethyl cellulose sodium ophthalmic solution. Scores of dry eye subjective symptoms, corneal fluorescein staining (FL), tear secretion test (S 鈪，

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