【摘要】：目的以上海金山化工地區(qū)為調查對象,分析化工地區(qū)鼻咽癌的流行特點。 方法獲取金山地區(qū)與周圍奉賢、松江等地區(qū)的鼻咽癌發(fā)病率、死亡率資料,進行比較分析；收集2005年1月1日至2011年8月31日在復旦大學附屬金山醫(yī)院就診的全部金山籍初診、初治鼻咽癌患者共119例,根據(jù)就診時登記的信息,對性別、年齡、病理類型、首診癥狀及臨床分期等臨床資料進行統(tǒng)計分析。 結果金山地區(qū)2002-2007年鼻咽癌的平均發(fā)病率為2.505/105,與周圍的奉賢、松江等地區(qū)相比,發(fā)病率和死亡率無統(tǒng)計學差異(P0.05),與廣東、廣西等高發(fā)病地區(qū)相比,金山地區(qū)發(fā)病率較低,且無明顯的升高或降低趨勢；男女發(fā)病率之比為2.45：1,發(fā)病年齡集中在30-70歲,病理類型中以未分化癌和低分化癌為主,分別占45.38%和40.34%,臨床分期以Ⅱ期、Ⅲ期為主。 結論金山化工區(qū)屬鼻咽癌的非高發(fā)區(qū),腫瘤惡性程度較高,多數(shù)患者就診時已處于臨床中晚期。 目的以上海金山化工地區(qū)為調查對象,探討化工相關因素對鼻咽癌發(fā)病的影響。 方法采用病例-對照研究的方法,對108名于2005年1月1日至2011年8月31日在復旦大學附屬金山醫(yī)院就診的初發(fā)鼻咽癌的患者進行病因調查,然后對各因素進行單因素的logistic回歸分析,再將篩查出來的影響因素進行多因素的logistic回歸分析。調查內容主要為與化工相關的因素。 結果對化工相關因素進行單因素及多因素的logistic回歸分析,結果表明在化工地區(qū)接觸農藥(OR=3.68)和職業(yè)接觸化學物質(OR=3.89)是鼻咽癌發(fā)病主要的化學危險因素,而接觸過程中采取有效的防護措施可以降低危險度。 結論職業(yè)與化工企業(yè)相關可以增加鼻咽癌發(fā)病的風險,但接觸過程中有效的防護措施可以降低這一危險度。
[Abstract]:Objective to analyze the epidemic characteristics of nasopharyngeal carcinoma (NPC) in Jinshan chemical region of Shanghai. Methods the data of incidence and mortality of nasopharyngeal carcinoma in Jinshan area, Fengxian and Songjiang areas were collected and analyzed, and all the patients who were admitted to Jinshan Hospital of Fudan University from January 1, 2005 to August 31, 2011 were collected. A total of 119 patients with nasopharyngeal carcinoma were treated. According to the information registered at the time of visit, the clinical data such as sex, age, pathological type, first diagnosis symptom and clinical stage were analyzed statistically. Results the average incidence of nasopharyngeal carcinoma in Jinshan from 2002 to 2007 was 2.505 / 105. There was no significant difference in morbidity and mortality between Jinshan and Fengxian and Songjiang (P0.05). Compared with high incidence areas such as Guangdong and Guangxi, the incidence of nasopharyngeal carcinoma in Jinshan was lower than that in Jinshan. The incidence ratio of male and female was 2.45: 1. The age of onset was 30-70 years old. The pathological types were mainly undifferentiated carcinoma and poorly differentiated carcinoma, accounting for 45.38% and 40.34%, respectively. The clinical stages were mainly stage 鈪，

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