阻塞性睡眠呼吸暫停綜合征與抑郁癥相關(guān)性的調(diào)查分析
發(fā)布時(shí)間：2018-08-21 10:26
【摘要】：過去20年中的臨床研究已經(jīng)表明阻塞性睡眠呼吸暫停綜合征（Obstructive SleepApnea Syndrome，OSA）與抑郁癥之間存在著密切的關(guān)系。近年來，由于人們生活水平的提高，且存在人口老齡化，根據(jù)人群年齡、性別和其他人口健康的特點(diǎn)而定，中老年患者存在兩種疾病的患病率可能會(huì)更高。研究表明：OSA可能會(huì)影響超過50%的65歲以上的人口，其中存在顯著抑郁癥的老年人可能占城市居住人口的26％以上。在臨床實(shí)踐中，隨訪有抑郁癥癥狀的OSA患者時(shí)，只考慮到其治療方法和治療反應(yīng)，另一方面，存在抑郁癥的OSA患者很少進(jìn)行抑郁癥的定期評(píng)估。然而，OSA不僅與抑郁癥的發(fā)生有關(guān)，而且OSA的存在也可能是抑郁癥藥物治療失敗的一個(gè)重要原因。提高對(duì)抑郁癥和OSA之間關(guān)系的認(rèn)識(shí)，可能會(huì)顯著改善疾病的診斷準(zhǔn)確率以及治療效果。在本研究中我們將對(duì)明確診斷為阻塞性睡眠呼吸暫停綜合征的88例患者進(jìn)行臨床資料分析，OSA與抑郁癥的相關(guān)性及其對(duì)臨床工作的影響進(jìn)行討論。 目的：探討阻塞性睡眠呼吸暫停綜合征與抑郁癥的相關(guān)性。 方法：采用描述性研究方法，對(duì)2009年9月-2011年5月在吉林大學(xué)第一醫(yī)院呼吸科睡眠實(shí)驗(yàn)室經(jīng)多導(dǎo)睡眠圖(Polysomno graphy，PSG)監(jiān)測(cè)確診的88例阻塞性睡眠呼吸暫停綜合征的患者進(jìn)行調(diào)查，主要調(diào)查工具有一般情況調(diào)查表、Epworth嗜睡量表（EpworthSleepiness Scale，ESS）、Zung抑郁自評(píng)量表(Self Rating DepressionScale，SDS)。所收集資料采用Excel建立數(shù)據(jù)庫(kù)，，采用SPSS13.0軟件進(jìn)行統(tǒng)計(jì)分析。 結(jié)果：88例OSA患者中抑郁癥的發(fā)生率為47.7%，明顯高于對(duì)照組的13.3%。輕、中、重度OSA患者抑郁癥的發(fā)生率分別為22.7%、44.4%、70.0%。88例OSA中，隨著BIM、AHI、ESS得分的升高，夜間SaO2min的降低，抑郁得分越高。 結(jié)論：1、OSA與抑郁癥具有相關(guān)性，在OSA患者中抑郁癥的發(fā)生率隨著OSA病情的加重而增加。2、88例OSA中，抑郁得分與BMI、AHI、ESS呈正相關(guān)，與最低血氧飽和度呈負(fù)相關(guān)。3、OSA患者應(yīng)警惕抑郁癥的發(fā)生，抑郁癥的調(diào)查應(yīng)在OSA患者中常規(guī)進(jìn)行，有助于臨床診斷及治療。
[Abstract]:Clinical studies over the past 20 years have shown a close relationship between obstructive sleep apnea syndrome (Obstructive SleepApnea) and depression. In recent years, due to the improvement of people's living standard and the aging of population, the prevalence of two diseases in middle-aged and elderly patients may be higher according to the characteristics of population age, sex and other population health. Studies show that OSA may affect more than 50 percent of the population over 65, with significant depression likely to account for more than 26 percent of the urban population. In clinical practice, only the treatment and response of OSA patients with depression symptoms are taken into account when following up. On the other hand, OSA patients with depression are rarely evaluated regularly for depression. However, OSA is not only related to the occurrence of depression, but also the existence of OSA may be an important reason for the failure of drug therapy for depression. Raising awareness of the relationship between depression and OSA may significantly improve the diagnostic accuracy and therapeutic effectiveness of the disease. In this study, we will analyze the clinical data of 88 patients with obstructive sleep apnea syndrome (OSAS) and discuss the relationship between OSA and depression and its influence on clinical work. Objective: to investigate the relationship between obstructive sleep apnea syndrome (OSAS) and depression. Methods: from September 2009 to May 2011, 88 patients with obstructive sleep apnea syndrome (OSAS) who were monitored by Polysomno map in the sleep laboratory of Department of Respiratory, first Hospital of Jilin University were investigated by descriptive method. The main survey tools were EpworthSleepiness scale (EpworthSleepiness scale) and Zung self rating Depression scale (Self Rating DepressionScale scale SDS). Excel was used to set up the database and SPSS13.0 software was used for statistical analysis. Results the incidence of depression in 88 OSA patients was 47. 7%, which was significantly higher than that in the control group (13. 3%). The incidence of depression in patients with mild, moderate and severe OSA was 22.74.4and 70.0in 88 cases of OSA. The higher the score of SaO2min was, the higher the score of depression was. Conclusion the incidence of depression in OSA patients increased with the exacerbation of OSA in 88 cases of OSA. The score of depression was positively correlated with BMIAHI ESS. The patients with OSA and the lowest oxygen saturation should be on guard against the occurrence of depression, and the investigation of depression should be carried out routinely in the patients with OSA, which is helpful for clinical diagnosis and treatment.
【學(xué)位授予單位】：吉林大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2012
【分類號(hào)】：R766;R749.4
本文編號(hào)：2195414
[Abstract]:Clinical studies over the past 20 years have shown a close relationship between obstructive sleep apnea syndrome (Obstructive SleepApnea) and depression. In recent years, due to the improvement of people's living standard and the aging of population, the prevalence of two diseases in middle-aged and elderly patients may be higher according to the characteristics of population age, sex and other population health. Studies show that OSA may affect more than 50 percent of the population over 65, with significant depression likely to account for more than 26 percent of the urban population. In clinical practice, only the treatment and response of OSA patients with depression symptoms are taken into account when following up. On the other hand, OSA patients with depression are rarely evaluated regularly for depression. However, OSA is not only related to the occurrence of depression, but also the existence of OSA may be an important reason for the failure of drug therapy for depression. Raising awareness of the relationship between depression and OSA may significantly improve the diagnostic accuracy and therapeutic effectiveness of the disease. In this study, we will analyze the clinical data of 88 patients with obstructive sleep apnea syndrome (OSAS) and discuss the relationship between OSA and depression and its influence on clinical work. Objective: to investigate the relationship between obstructive sleep apnea syndrome (OSAS) and depression. Methods: from September 2009 to May 2011, 88 patients with obstructive sleep apnea syndrome (OSAS) who were monitored by Polysomno map in the sleep laboratory of Department of Respiratory, first Hospital of Jilin University were investigated by descriptive method. The main survey tools were EpworthSleepiness scale (EpworthSleepiness scale) and Zung self rating Depression scale (Self Rating DepressionScale scale SDS). Excel was used to set up the database and SPSS13.0 software was used for statistical analysis. Results the incidence of depression in 88 OSA patients was 47. 7%, which was significantly higher than that in the control group (13. 3%). The incidence of depression in patients with mild, moderate and severe OSA was 22.74.4and 70.0in 88 cases of OSA. The higher the score of SaO2min was, the higher the score of depression was. Conclusion the incidence of depression in OSA patients increased with the exacerbation of OSA in 88 cases of OSA. The score of depression was positively correlated with BMIAHI ESS. The patients with OSA and the lowest oxygen saturation should be on guard against the occurrence of depression, and the investigation of depression should be carried out routinely in the patients with OSA, which is helpful for clinical diagnosis and treatment.
【學(xué)位授予單位】：吉林大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2012
【分類號(hào)】：R766;R749.4
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