【摘要】：目的:探討初診未行治療的原發(fā)性開角型青光眼(primary open angle glaucoma,POAG)患者習(xí)慣性體位眼壓及眼灌注壓(ocular perfusion pressure,OPP)波動趨勢,并驗(yàn)證由日間平均坐位及臥位眼壓推導(dǎo)夜間峰值眼壓的可行性。方法:選取POAG患者19例19眼及正常對照組18例18眼,分別于10∶00,14∶00,18∶00及22∶00時行坐位眼壓及血壓監(jiān)測,為驗(yàn)證由日間臥位眼壓推導(dǎo)夜間峰值眼壓的可行性,另對POAG組于臥位5min后再行監(jiān)測。2∶00,5∶00及7∶00行臥位監(jiān)測,計(jì)算出OPP并行數(shù)據(jù)分析。由已知公式通過日間眼壓計(jì)算夜間峰值眼壓,并與實(shí)際值對比。結(jié)果:24h習(xí)慣性體位下,POAG患者平均眼壓及眼壓波動均高于正常對照組(P0.05),POAG組平均眼壓峰值出現(xiàn)于凌晨5∶00,對照組則為7∶00。兩組夜間眼壓均值均大于日間,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。兩組內(nèi)習(xí)慣性體位平均眼灌注壓(MOPP)均表現(xiàn)為夜間低于日間(P0.05),而兩組間MOPP無明顯統(tǒng)計(jì)學(xué)差異(P0.05)。POAG患者M(jìn)OPP波動較對照組大,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。由兩公式推導(dǎo)所得夜間眼壓峰值均與所測值無明顯統(tǒng)計(jì)學(xué)差異(P0.05)。結(jié)論:習(xí)慣性體位下POAG組及正常人的眼壓峰值多出現(xiàn)在凌晨至上午,POAG患者的習(xí)慣性體位平均眼壓及眼壓波動均高于對照組。兩組內(nèi)夜間灌注壓均較日間低,且POAG患者有更大的MOPP波動。由日間眼壓推導(dǎo)夜間峰值眼壓具有一定的可行性。
[Abstract]:Objective: to investigate the fluctuation tendency of habitual position pressure (IOP) and intraocular perfusion pressure (IOP) in patients with primary open angle glaucoma (primary open angle glaucoma Poag), and to verify the feasibility of deriving nocturnal peak IOP from daytime mean sitting position and supine IOP. Methods: intraocular pressure (IOP) and blood pressure monitoring were performed in 19 patients with POAG (19 eyes) and 18 normal subjects (18 eyes) at 10: 00 to 14: 00 and 22:00, respectively, in order to verify the feasibility of deducing nocturnal peak intraocular pressure from daytime lying intraocular pressure. In addition, the POAG group was monitored again after lying 5min. 2: 00: 5: 00 and 7:00. The parallel data of OPP were calculated and analyzed. The nocturnal peak IOP was calculated by the known formula and compared with the actual value. Results the mean intraocular pressure and intraocular pressure fluctuation in Poag group were higher than those in normal control group (P0.05). The peak of IOP in Poag group was 5: 00 in the morning and 7: 00 in control group. The mean nocturnal IOP in the two groups was higher than that in the daytime, and the difference was statistically significant (P0.05). The mean intraocular perfusion pressure (MOPP) of the two groups was significantly lower than that of the daytime (P0.05), but there was no significant difference in MOPP between the two groups (P0.05). The MOPP fluctuation of Poag patients was larger than that of the control group (P0.05). The nocturnal IOP peak was not significantly different from the measured values (P0.05). Conclusion: the peak of IOP in POAG group and normal subjects was higher than that in control group from early morning to morning in Poag patients. The nocturnal perfusion pressure in both groups was lower than that in daytime, and MOPP fluctuated more in patients with POAG. It is feasible to deduce nocturnal peak IOP from daytime IOP.
【作者單位】： 安徽醫(yī)科大學(xué)附屬北京大學(xué)深圳醫(yī)院北京大學(xué)深圳醫(yī)院眼科;
【分類號】：R775.2

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