【摘要】：目的:初步探討慢性鼻-鼻竇炎的臨床表型及炎性特征。方法:選取25例慢性鼻-鼻竇炎伴鼻息肉(CRSwNP)患者和23例慢性鼻-鼻竇炎不伴鼻息肉(CRSsNP)患者為研究對(duì)象,分析2種類型患者的臨床特征(癥狀VAS評(píng)分、鼻內(nèi)鏡檢查的Lanza-Kennedy評(píng)分、鼻竇CT的Lund-Mackay評(píng)分),比較病變組織中嗜酸粒細(xì)胞與中性粒細(xì)胞的分布情況,分析炎性標(biāo)記物IL-5、IL-17、IFN-γ的表達(dá)情況。結(jié)果:CRSwNP患者的鼻塞VAS評(píng)分、鼻內(nèi)鏡評(píng)分及鼻竇CT評(píng)分均高于CRSsNP患者(P0.05)。蘇木精-伊紅染色顯示,2種類型患者病變組織均為炎性細(xì)胞混合浸潤(rùn)。CRSwNP患者中10例以嗜酸粒細(xì)胞浸潤(rùn)為主,15例以嗜中性粒細(xì)胞為主;CRSsNP患者中18例以嗜酸粒細(xì)胞為主,5例以嗜中性粒細(xì)胞為主。CRSwNP患者IL-5、IL-17、IFN-γ的表達(dá)明顯高于CRSsNP患者(P0.05)。結(jié)論:CRSwNP患者的臨床表現(xiàn)及炎癥程度比CRSsNP患者更嚴(yán)重。CRSwNP與CRSsNP病變黏膜組織均為炎性細(xì)胞混合浸潤(rùn)。
[Abstract]:Objective: to investigate the clinical phenotype and inflammatory characteristics of chronic rhinosinusitis. Methods: 25 patients with chronic rhinosinusitis with nasal polyps (CRSwNP) and 23 patients with chronic rhinosinusitis (CRSsNP) without nasal polyps were selected as subjects. The clinical features (symptom VAS score, Lanza-Kennedy score of nasal endoscopy) were analyzed. The distribution of eosinophils and neutrophils was compared and the expression of IL-5 and IL-17 IFN- 緯 was analyzed. Results the nasal congestion VAS score, nasal endoscopy score and sinus CT score were higher in the patients than those in the patients with CRSsNP (P0.05). Hematoxylin-eosin staining showed that the pathological tissues of two types of patients were inflammatory cell mixed infiltration. 10 cases of CRSwNP patients were mainly eosinophil infiltration 15 cases were mainly neutrophils and 18 cases were eosinophils. The expression of IL-5, IL-17 and IFN- 緯 in 5 patients with primary neutrophils was significantly higher than that in patients with CRSsNP (P0.05). Conclusion the clinical manifestations and inflammation degree of the patients with CRSsNP are more serious than those of the patients with CRSsNP. The mucosal tissues of the lesions of CRSwNP and CRSsNP are mixed infiltration of inflammatory cells.
【作者單位】： 解放軍總醫(yī)院耳鼻咽喉頭頸外科;中國(guó)民用航空醫(yī)學(xué)中心(民航總醫(yī)院)空勤人員體檢鑒定所;解放軍總醫(yī)院病理科;解放軍總醫(yī)院海南分院耳鼻咽喉頭頸外科;
【基金】：國(guó)家自然科學(xué)基金(No:81371074,No:81670901)
【分類號(hào)】：R765

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