本文選題：化膿性扁桃體炎 + 抗生素相關(guān)性腹瀉��； 參考：《中國現(xiàn)代醫(yī)學(xué)雜志》2016年05期

【摘要】：目的觀察益生菌對抗生素治療化膿性扁桃體炎所繼發(fā)抗生素相關(guān)性腹瀉(AAD)是否有預(yù)防作用。方法選擇鄭州市兒童醫(yī)院門急診使用廣譜抗生素治療537例化膿性扁桃體炎患兒。其中353例完成研究,將該353例化膿性扁桃體炎患兒隨機分為干預(yù)組和對照組,干預(yù)組在抗生素治療第1天加用益生菌,抗生素停止后繼續(xù)應(yīng)用3 d,觀察組僅用抗生素,觀察其出現(xiàn)AAD時間及數(shù)量。結(jié)果兩組患兒入組前后抗生素使用種類、途徑及時間比較,差異無統(tǒng)計學(xué)意義,治療隨訪結(jié)束時,干預(yù)組累計有22例發(fā)生AAD,發(fā)生率為11.17%,顯著低于對照組的23.08%(χ~2=8.993,P=0.003),兩者比較差異有統(tǒng)計學(xué)意義(P0.01),且ADD發(fā)生時間明顯后移。危險度分析顯示,相對于對照組,應(yīng)用益生菌治療后AAD發(fā)生風(fēng)險降低58.1%。且腹瀉發(fā)生時間除第1天外各組間比較差異有統(tǒng)計學(xué)意義(P0.05)。在整個治療觀察期間無益生菌相關(guān)不良反應(yīng)。結(jié)論益生菌可以減低化膿性扁桃體炎抗生素治療后AAD的發(fā)生,化膿性扁桃體炎患兒加用益生菌治療是有益的。未發(fā)現(xiàn)其不良反應(yīng)。
[Abstract]:Objective to observe the preventive effect of probiotics on antibiotic associated diarrhea (AAD) secondary to suppurative tonsillitis. Methods 537 children with suppurative tonsillitis were treated with broad-spectrum antibiotics in outpatient and emergency department of Zhengzhou Children's Hospital. 353 children with suppurative tonsillitis were randomly divided into the intervention group and the control group. The intervention group was treated with probiotics on the first day of antibiotic treatment. The time and quantity of AAD were observed. Results there was no significant difference in the use of antibiotics between the two groups before and after entering the group, and there was no significant difference between the two groups. In the intervention group, 22 cases (11.17%) developed AAD, which was significantly lower than that in the control group (23.08%) (蠂 ~ (2 / 2) ~ (8.993) P ~ (0.003). The difference between the two groups was statistically significant (P0.01), and the onset time of add was obviously shifted back. Risk analysis showed that compared with the control group, the risk of AAD was reduced by 58.1% after probiotics therapy. Besides the first day, there were significant differences in the time of diarrhea (P0.05). There were no probiotic related adverse reactions during the treatment observation period. Conclusion probiotics can reduce the incidence of AAD in children with suppurative tonsillitis after antibiotic therapy, and it is beneficial to treat children with suppurative tonsillitis with probiotics. No adverse reactions were found.
【作者單位】： 河南省鄭州市兒童醫(yī)院急診科;河南省鄭州市兒童醫(yī)院心電圖室;
【分類號】：R766.18
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本文編號：2085006