本文選題：角膜損傷修復(fù) + 轉(zhuǎn)化生長因子-β　； 參考：《眼科新進展》2017年02期

【摘要】：角膜損傷后的纖維化修復(fù)是角膜瘢痕形成的主要原因。轉(zhuǎn)化生長因子-β(transforming growth factor-beta,TGF-β)在角膜的穩(wěn)態(tài)平衡中起著至關(guān)重要的作用,是角膜損傷修復(fù)的重要參與者。同時,角膜上皮基底膜是角膜創(chuàng)傷修復(fù)過程中角膜上皮與基質(zhì)相互作用的重要屏障。角膜損傷修復(fù)的不同階段,各亞型TGF-β在角膜各種細胞及各個不同部位存在著分布差異,角膜上皮基底膜是否完整是影響該過程的重要因素。TGF-β不同亞型在時間和空間上的分布差異及變化與角膜的創(chuàng)傷修復(fù)過程中細胞的遷移、增殖、表型變化及細胞外基質(zhì)沉著都緊密相關(guān),是瘢痕愈合及無瘢痕愈合的細胞分子生物學(xué)基礎(chǔ)。本文就TGF-β的生物學(xué)功能及其亞型在角膜損傷修復(fù)中的時間和空間分布情況作一綜述。
[Abstract]:The repair of corneal fibrosis after corneal injury is the main cause of corneal scar formation. Transforming growth factor- 尾 (transforming growth factor-beta- 尾 (TGF- 尾) plays an important role in the homeostasis of cornea and plays an important role in corneal injury repair. At the same time, corneal epithelial basement membrane is an important barrier to the interaction between corneal epithelium and stroma during corneal wound repair. In different stages of corneal injury repair, the distribution of TGF- 尾 was different in various corneal cells and different parts of cornea. Whether the corneal epithelial basement membrane is intact or not is an important factor affecting the process. The time and space distribution of different subtypes of TGF- 尾 and the changes of the corneal epithelial basement membrane are related to the migration and proliferation of the cells in the process of corneal wound repair. Phenotypic changes and extracellular matrix deposition are closely related, which is the cellular molecular biological basis of scar healing and scarless healing. This paper reviews the biological function of TGF- 尾 and the temporal and spatial distribution of TGF- 尾 subtypes in corneal injury repair.
【作者單位】： 廣西醫(yī)科大學(xué)第一附屬醫(yī)院眼科;
【基金】：國家自然科學(xué)基金資助(編號:81060076;81360144)~~
【分類號】：R772.2

【參考文獻】

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本文編號：2084608