本文選題：胎盤多肽注射液 + 鼻咽癌��； 參考：《西部醫(yī)學(xué)》2016年09期

【摘要】：目的觀察胎盤多肽注射液聯(lián)合放化療治療中晚期鼻咽癌的近期療效和不良反應(yīng)。方法將56例中晚期鼻咽癌患者隨機(jī)分為治療組28例和對照組28例,兩組患者均接受調(diào)強(qiáng)適形放射治療(intensity modulated radiation therapy,IMRT),同時(shí)予順鉑同步化療,40mg/m2,每周1次,治療組在此基礎(chǔ)上加用胎盤多肽注射液輔助治療。比較兩組患者近期療效和不良反應(yīng)。結(jié)果兩組患者均完成同步放化療,兩組總有效率無明顯差異(P0.05);但治療組患者體力狀況評分較對照組明顯改善,差異有統(tǒng)計(jì)學(xué)意義(醊2=5.203,P=0.023)。治療組Ⅲ/Ⅳ度白細(xì)胞減少發(fā)生率明顯低于對照組(P0.05);口腔黏膜炎及放射性皮膚反應(yīng)發(fā)生率均明顯低于對照組(P0.05)。結(jié)論胎盤多肽注射液聯(lián)合同步放化療治療中晚期鼻咽癌有一定的輔助作用,能改善患者的體力狀態(tài),減輕或降低同步放化療引起的毒副作用,無明顯不良反應(yīng),值得臨床進(jìn)一步推廣應(yīng)用。
[Abstract]:Objective to observe the efficacy and side effects of placental polypeptide injection combined with radiotherapy and chemotherapy in the treatment of advanced nasopharyngeal carcinoma. Methods Fifty-six patients with advanced nasopharyngeal carcinoma were randomly divided into two groups: treatment group (n = 28) and control group (n = 28). All patients in both groups were treated with intensity modulated radiotherapy (IMRT) and 40 mg / m ~ (2) cisplatin chemotherapy, once a week. The treatment group was treated with placental polypeptide injection. The short-term curative effect and adverse reaction were compared between the two groups. Results there was no significant difference in the total effective rate between the two groups (P0.05), but the scores of physical condition of the patients in the treatment group were significantly improved compared with the control group, and the difference was statistically significant (P < 0.05). The incidence of leukopenia in the treatment group was significantly lower than that in the control group (P0.05), while the incidence of oral mucositis and radiation skin reaction was significantly lower in the treatment group than in the control group (P0.05). Conclusion placental polypeptide injection combined with concurrent radiotherapy and chemotherapy can improve the physical state of patients with advanced nasopharyngeal carcinoma, alleviate or reduce the side effects caused by concurrent radiotherapy and chemotherapy, and have no obvious adverse reactions. It is worthy of further clinical application.
【作者單位】： 四川省醫(yī)學(xué)科學(xué)院·四川省人民醫(yī)院腫瘤科;
【基金】：四川省科技支撐計(jì)劃項(xiàng)目(2015S2087)
【分類號】：R739.63

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