本文選題：復方苦參注射液 + 鼻咽癌�。� 參考：《中南醫(yī)學科學雜志》2016年06期

【摘要】：目的系統(tǒng)評價復方苦參注射液輔助放化療治療鼻咽癌的有效性和安全性,為臨床治療提供循證參考。方法計算機檢索The Cochrane Library、Medline、EMbase、CBM、CNKI、VIP、萬方數(shù)據(jù)庫,收集復方苦參注射液聯(lián)合放化療(試驗組)對照單純放化療(對照組)治療鼻咽癌的隨機對照試驗(RCTs),提取資料并評價質量后,采用Rev Man 5.3統(tǒng)計軟件對完全緩解率、Ⅲ~Ⅳ級口腔黏膜炎發(fā)生率、Ⅲ~Ⅳ級放射性皮炎發(fā)生率、Ⅲ~Ⅳ級白細胞減少發(fā)生率進行Meta分析。結果共納入7項RCT,合計328例患者。Meta分析結果顯示,觀察組患者治療完全緩解率[OR=2.00,95%CI(1.27,3.13),P0.05]、Ⅲ~Ⅳ級口腔黏膜炎發(fā)生率[OR=0.35,95%CI(0.24,0.51),P0.05]、Ⅲ~Ⅳ級放射性皮炎發(fā)生率[OR=0.39,95%CI(0.25,0.60),P0.05]、Ⅲ~Ⅳ級白細胞減少發(fā)生率[OR=0.41,95%CI(0.28,0.58),P0.05]顯著優(yōu)于對照組,兩組比較差異均有統(tǒng)計學意義。結論復方苦參注射液輔助放化療治療鼻咽癌療效與安全性均更好。受納入研究方法學的局限性,該結論有待更多高質量、大樣本、長期隨訪的RCTs進一步驗證。
[Abstract]:Objective to evaluate the efficacy and safety of compound Sophora flavescens injection in the treatment of nasopharyngeal carcinoma (NPC). Methods the Cochrane Library Medline was searched by computer, and the database of compound Sophora flavescens injection combined with radiotherapy and chemotherapy (trial group) was collected. The RCTs were collected from RCTs for nasopharyngeal carcinoma (NPC) treatment. The data were extracted and the quality was evaluated. The complete remission rate, the incidence of oral mucositis in grade 鈪，

本文編號：2078166