本文選題：曲伏前列腺素 + 原發(fā)性開角型青光眼�。� 參考：《中國臨床藥理學(xué)雜志》2016年22期

【摘要】：目的觀察曲伏前列腺素滴眼液對原發(fā)性開角型青光眼患者眼壓及血漿中內(nèi)皮素~(-1)的影響。方法 80例原發(fā)性開角型青光眼患者隨機(jī)分為試驗組40例和對照組40例。對照組給予馬來酸噻嗎洛爾滴眼液,每次1滴,早晚各1次。試驗組給予曲伏前列腺素滴眼液,每次1滴,睡前1次。2組均長期持續(xù)治療。比較2組治療前和治療后3個月的眼壓及血漿中內(nèi)皮素~(-1)的變化情況。結(jié)果治療后,試驗組的平均眼壓為(17.12±1.80)mm Hg,對照組為(19.02±1.55)mm Hg(P0.05)。治療后,試驗組的前后晝夜眼壓差為(3.92±0.89)mm Hg,對照組為(4.55±0.96)mm Hg(P0.05)。治療后,試驗組視網(wǎng)膜中央動脈(CRA)的收縮期峰速(PSV)為(10.79±2.15)cm·s~(-1),舒張末期流速(EDV)為(3.75±0.74)cm·s~(-1),阻力指數(shù)為0.61±0.05;對照組的PSV為(8.67±1.77)cm·s~(-1),EDV為(2.71±0.72)cm·s~(-1),阻力指數(shù)為0.67±0.12,2組差異有統(tǒng)計學(xué)意義(P0.05)。治療后,試驗組睫狀后動脈(PCA)的PSV為(13.23±3.16)cm·s~(-1),EDV為(3.75±0.70)cm·s~(-1),阻力指數(shù)為0.65±0.07;對照組的PSV為(9.91±2.56)cm·s~(-1),EDV為(2.72±0.73)cm·s~(-1),阻力指數(shù)為0.74±0.10,2組差異有統(tǒng)計學(xué)意義(P0.05)。治療后,試驗組血漿內(nèi)皮素~(-1)水平為(45.22±7.56)ng·L~(-1),對照組為(49.32±8.05)ng·L~(-1)(P0.05)。對照組出現(xiàn)眼部不適3例,眼部輕度干澀5例,藥物不良反應(yīng)發(fā)生率為20.00%(8/40例);試驗組出現(xiàn)睫毛增粗2例,眼紅4例,眼部輕度干澀4例,藥物不良反應(yīng)發(fā)生率為25.00%(10/40例),差異無統(tǒng)計學(xué)意義(P0.05)。結(jié)論曲伏前列腺素對原發(fā)性開角型青光眼患者的臨床療效良好,可以降低患者的眼壓和患者血漿內(nèi)皮素~(-1)水平。
[Abstract]:Objective to observe the effect of travoprostaglandin eye drops on intraocular pressure and plasma endothelin-1 in patients with primary open angle glaucoma. Methods 80 patients with primary open angle glaucoma were randomly divided into trial group (n = 40) and control group (n = 40). The control group was given tiamolol maleate eye drops, 1 drop each time, 1 time in the morning and evening. The experimental group was treated with travoprostaglandin eye drops, 1 drop each time and 1 time before bedtime. 2 groups were treated continuously for a long time. Intraocular pressure (IOP) and endothelin-1 (et-1) in plasma were compared before and 3 months after treatment in both groups. Results after treatment, the mean intraocular pressure was (17.12 鹵1.80) mm Hg in the experimental group and (19.02 鹵1.55) mm Hg in the control group (P0.05). After treatment, the intraocular pressure difference was (3.92 鹵0.89) mm Hg in the experimental group and (4.55 鹵0.96) mm Hg in the control group (P0.05). After treatment, the peak systolic velocity (PSV), end-diastolic velocity (EDV) and resistance index of central retinal artery (CRA) were (10.79 鹵2.15) cm s ~ (-1), (3.75 鹵0.74) cm s ~ (-1) and (0.61 鹵0.05) in the experimental group, and (8.67 鹵1.77) cm s ~ (-1) EDV in the control group, respectively (2.71 鹵0.72) cm s ~ (-1) and (0.67 鹵0.122) cm s ~ (-1), respectively (P0.05). After treatment, PSV of posterior ciliary artery (PCA) was (13.23 鹵3.16) cm s ~ (-1) EDV was (3.75 鹵0.70) cm s ~ (-1), resistance index was 0.65 鹵0.07 in experimental group, and PSV in control group was (9.91 鹵2.56) cm s ~ (-1) EDV (2.72 鹵0.73) cm s ~ (-1), resistance index was 0.74 鹵0.102 (P0.05). After treatment, the level of plasma endothelin 1 was (45.22 鹵7.56) ng / L ~ (-1) in the experimental group and (49.32 鹵8.05) ng / L ~ (-1) in the control group (P0.05). In the control group, there were 3 cases of ocular discomfort, 5 cases of mild dry eye, the incidence of adverse drug reaction was 20.00% (8 / 40 cases), the test group had 2 cases of eyelash thickening, 4 cases of eye red and 4 cases of mild dry eye. The incidence of adverse drug reactions was 25.00% (10 / 40 cases) with no significant difference (P0.05). Conclusion Travoprostaglandin has a good clinical effect on patients with primary open-angle glaucoma. It can reduce intraocular pressure and plasma endothelin ~ (-1) levels in patients with primary open-angle glaucoma.
【作者單位】： 浙江醫(yī)院眼科;溫州醫(yī)科大學(xué)附屬眼視光醫(yī)院屈光手術(shù)中心;
【基金】：溫州市科技計劃基金資助項目(Y20140396)
【分類號】：R775.2

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