本文選題：紫外光輻照 + 人工晶狀體　； 參考：《浙江大學(xué)》2015年博士論文

【摘要】：目的： 利用先進(jìn)的紫外光輻照技術(shù)接枝親水性單體,實(shí)現(xiàn)疏水性人工晶狀體(IOL)前表面親水化改性,保留后表面的疏水特性,探討一種能夠提高IOL生物相容性的簡(jiǎn)單、經(jīng)濟(jì)、高效的方法,以利于進(jìn)一步的工業(yè)化生產(chǎn)。 方法： 采用化學(xué)、物理兩種方法預(yù)處理疏水性丙烯酸酯人工晶體以實(shí)現(xiàn)活性引發(fā),采用紫外光輻照表面改性技術(shù)接枝親水性單體2-甲基丙烯酰氧基乙基磷酰膽堿(MPC)修飾疏水性聚丙烯酸酯IOL前表面。應(yīng)用靜態(tài)水接觸角(WCA)、X射線光電子能譜(XPS)及傅里葉變換紅外光譜(FT-IR)分別分析IOL表面親水性和表面化學(xué)元素組成變化；原子力顯微鏡(AFM)以考察改性后IOL表面形貌的改變。 結(jié)果： 靜態(tài)水接觸角檢測(cè)顯示經(jīng)紫外光輻照接枝處理后的IOL前表面親水性明顯增強(qiáng),靜態(tài)接觸角明顯下降(p0.01),接觸角變化程度與接枝時(shí)間有良好相關(guān) 性。紅外光譜、XPS分析進(jìn)一步證實(shí)了紫外光輻照接枝處理后IOL表面的極性 基團(tuán)的引入以及MPC的成功接枝。AFM觀察改性后IOL表面未出現(xiàn)明顯損傷, 粗糙度與處理前相比無(wú)明顯差異. 結(jié)論：紫外光輻照接枝技術(shù)能夠成功在疏水性聚丙烯酸酯IOL前表面接枝親水性 單體MPC,這種方法制造的新型人工晶體具有前表面親水后表面疏水的特性,具 有同時(shí)防止術(shù)眼前節(jié)炎癥和后囊膜渾濁等術(shù)后并發(fā)癥的潛力。該表面改性技術(shù)操 作流程簡(jiǎn)單、經(jīng)濟(jì)環(huán)保,可連續(xù)性作業(yè),具有良好的市場(chǎng)化前景。
[Abstract]:Objective: to realize the hydrophilic modification of the front surface of hydrophobic intraocular lens (IOL) and retain the hydrophobic properties of the surface of IOL by using the advanced ultraviolet irradiation technique to graft hydrophilic monomer, and to explore a simple method to improve the biocompatibility of IOL. Economic, efficient methods to facilitate further industrial production. Methods: hydrophobic acrylate intraocular lens was pretreated by chemical and physical methods in order to achieve active initiation. The front surface of hydrophobic polyacrylate IOL was modified by UV irradiation grafting of hydrophilic monomer 2-methacryloxy ethyl phosphatidylcholine (MPC). The surface hydrophilicity and chemical composition of IOL were analyzed by X-ray photoelectron spectroscopy (XPS) and Fourier transform infrared spectroscopy (FTIR), respectively, and the surface morphology of the modified IOL was investigated by atomic force microscopy (AFM). Results: the static water contact angle test showed that the surface hydrophilicity of IOL grafted by UV irradiation was obviously enhanced, and the static contact angle was obviously decreased (p 0.01). The change of contact angle had good correlation with grafting time. FTIR XPS analysis further confirmed the introduction of polar groups on the surface of IOL after UV irradiation grafting and the successful grafting of MPC. AFM observed that the surface of the modified IOL was not obviously damaged and rough. There was no significant difference in degree between before treatment and before treatment. Conclusion: the UV irradiation grafting technique can successfully graft hydrophobic polyacrylate IOL onto the hydrophilic monomer MPC.The new intraocular crystal prepared by this method has the characteristics of hydrophilicity and hydrophobicity. It has the potential to prevent postoperative complications such as anterior segment inflammation and posterior capsule opacification. The surface modification technology has the advantages of simple operation flow, economic and environmental protection, continuous operation and good market prospect.
【學(xué)位授予單位】：浙江大學(xué)
【學(xué)位級(jí)別】：博士
【學(xué)位授予年份】：2015
【分類(lèi)號(hào)】：R779.66

【參考文獻(xiàn)】

相關(guān)期刊論文 前9條

1 ;F-heparin modified intraocular lenses in Rhesus monkeys[J];International Journal of Ophthalmology;2010年02期

2 王桂琴,何炳林,顧漢卿,李晨曦,劉曉航,林松;表面修飾硅凝膠人工晶狀體表面特性檢測(cè)[J];南開(kāi)大學(xué)學(xué)報(bào)(自然科學(xué)版);2002年03期

3 鄭志雯;焦燕;任力;王迎軍;;聚甲基丙烯酸酯人工晶狀體表面水蛭素修飾及抗黏附[J];中國(guó)科學(xué):技術(shù)科學(xué);2014年06期

4 王桂琴,湯欣,何炳林,顧漢卿;表面修飾硅凝膠人工晶狀體植入兔眼的實(shí)驗(yàn)研究[J];透析與人工器官;2000年02期

5 袁佳琴,孫慧敏,徐延山,郭紅玉,王桂琴,顧漢卿,祁明信,黃秀榕;氟-肝素表面修飾人工晶狀體的實(shí)驗(yàn)研究[J];眼科新進(jìn)展;2003年03期

6 吳仁毅,姚克,孫朝暉,徐雯,陳佩卿;牛晶狀體上皮細(xì)胞在不同材料人工晶狀體表面生長(zhǎng)的比較研究[J];中華眼科雜志;2000年05期

7 王洋;韓宏光;;人工晶體材料的生物相容性特征[J];中國(guó)組織工程研究;2013年25期

8 余琦;周煉紅;田明星;;多西紫杉醇修飾的人工晶體對(duì)眼組織相容性的影響[J];湖北科技學(xué)院學(xué)報(bào)(醫(yī)學(xué)版);2014年04期

9 王桂琴;曹利群;李娜;彭秀軍;唐慧琴;董亞利;顧漢卿;;表面修飾疏水性丙烯酸酯人工晶狀體表面超微結(jié)構(gòu)的觀察[J];眼科新進(jìn)展;2014年10期

，

本文編號(hào)：2028019