本文選題：阻塞性睡眠呼吸暫停低通氣綜合征 + 糖化血紅蛋白�。� 參考：《中國(guó)老年學(xué)雜志》2017年09期

【摘要】：目的探討阻塞性睡眠呼吸暫停低通氣綜合征(OSAHS)患者糖化血紅蛋白(Hb A1c)升高的相關(guān)因素。方法選取173例OSAHS患者,檢測(cè)Hb A1c,并按標(biāo)準(zhǔn)分為Hb A1c升高組(53例),Hb A1c正常組(120例),應(yīng)用SPSS21.0軟件進(jìn)行統(tǒng)計(jì)學(xué)分析。結(jié)果兩組腰圍身高比(WHtR)、呼吸暫停指數(shù)(AHI)、血氧飽和度(SaO_2)低于90%所占時(shí)間比(CT90%)、最低SaO_2(LSaO_2)、平均SaO_2(MSaO_2)、總呼吸暫停時(shí)間、最長(zhǎng)呼吸暫停時(shí)間、氧減指數(shù)、腰圍、頸圍及OSAHS嚴(yán)重程度差異有統(tǒng)計(jì)學(xué)意義(均P0.05)。LSaO_2、MSaO_2與Hb A1c呈負(fù)相關(guān)(r=-0.222、-0.166,WHtR、CT90%、氧減指數(shù)、AHI、總呼吸暫停時(shí)間、腰圍分別與Hb A1c呈正相關(guān)(r=0.276、0.216、0.251、0.209、0.166、0.272)。二元Logistic回歸分析示:LSaO_2、WHtR進(jìn)入模型(OR=0.950、2.052,P=0.001、0.007)。結(jié)論 OSAHS與Hb A1c升高密切相關(guān),慢性間歇缺氧和中心性肥胖是OSAHS患者Hb A1c升高的獨(dú)立危險(xiǎn)因素。
[Abstract]:Objective to investigate the related factors of elevated HbA1c in patients with obstructive sleep apnea hypopnea syndrome (OSAHS). Methods 173 patients with OSAHS were selected to detect HbA1c, and were divided into 53 patients with elevated HbA1c and 120 patients with normal HbA1c. SPSS 21.0 software was used for statistical analysis. Results the ratio of waist circumference to height, apnea index (AHI), saturation of blood oxygen (SaO2) less than 90% in the two groups were less than CT90, and the lowest SaO2T / LSaO2C, the average SaO2S / MSaO2S, the total apnea time, the longest apnea time, the oxygen reduction index, waist circumference, There were significant differences in the neck circumference and the severity of OSAHS (all P0.05N. LSaO2MSaOS-2 and HbA1c were negatively correlated with HbA1c, oxygen reduction index (AHI), total apnea time and waist circumference were positively correlated with HB A1c. The binary logistic regression analysis showed that the weight of LSaOs 2WHtR entered the model OR0.950 / 2.052P0. 001 / 0.007. Conclusion OSAHS is closely associated with the increase of HbA1c. Chronic intermittent hypoxia and central obesity are independent risk factors for HbA1c elevation in OSAHS patients.
【作者單位】： 鄭州大學(xué)第一附屬醫(yī)院河南省呼吸疾病研究所河南省高等學(xué)校臨床醫(yī)學(xué)重點(diǎn)學(xué)科開放實(shí)驗(yàn)室;
【基金】：衛(wèi)生部國(guó)家臨床重點(diǎn)�？平ㄔO(shè)項(xiàng)目(衛(wèi)辦醫(yī)政函〔2012〕649號(hào))
【分類號(hào)】：R766
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本文編號(hào)：2001246