本文選題：阻塞性睡眠呼吸暫停低通氣綜合征 + 解偶聯(lián)蛋白-2��； 參考：《山西醫(yī)科大學(xué)》2012年碩士論文

【摘要】：目的：觀察阻塞性睡眠呼吸暫停低通氣綜合征(OSAS)患者糖代謝異常情況及血清解偶聯(lián)蛋白-2(UCP-2)的變化,探討OSAS并發(fā)糖代謝異常的可能機(jī)制。 方法：選取OSAS患者31例,分為輕中度組16人,重度組15人。選取OSAS合并2型糖尿病患者14人,單純2型糖尿病患者14人及單純肥胖者18例。各組間年齡、性別差異無顯著性。入選者均測(cè)量身高、體重,算出體重指數(shù)(BMI)。所有入選者行整夜多導(dǎo)睡眠監(jiān)測(cè)(PSG),分析得到睡眠呼吸暫停低通氣指數(shù)(AHI)、夜間最低血氧飽和度(LSaO2)。監(jiān)測(cè)次日晨7時(shí)抽取空腹靜脈血10ml,分別測(cè)定糖化血紅蛋白(HbA1c)、空腹血糖(FPG)及UCP-2水平,并比較各組間所有化驗(yàn)指標(biāo)的差異,行相關(guān)性分析。 結(jié)果：1.與肥胖對(duì)照組相比,其余各組FPG、HbA1C水平均明顯升高,差異有統(tǒng)計(jì)學(xué)意義(p0.05)。重度OSAS組、合并組、糖尿病組與輕中度OSAS組相比,升高更明顯,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。合并組、糖尿病組與重度組相比,升高更明顯(P0.05)。合并組與糖尿病組相比差異無統(tǒng)計(jì)學(xué)意義。 2.糖尿病組、重度OSAS組、合并組分別與對(duì)照組、輕中度組相比,UCP-2水平明顯升高,差異有統(tǒng)計(jì)學(xué)意義(p0.05)。合并組與糖尿病組、重度組相比升高明顯(p0.05)。輕中度組與對(duì)照組相比,差異無統(tǒng)計(jì)學(xué)意義。重度組與糖尿病組相比差異不明顯。 3.相關(guān)分析顯示UCP-2水平與AHI、HbA1c、FPG成正相關(guān)(r=0.795,0.513,0.268,p0.05),與LSO2呈負(fù)相關(guān)(r=-0.721,p0.05)。 結(jié)論：1.OSAS患者存在糖代謝異常,并與OSAS嚴(yán)重程度有關(guān)； 2.OSAS可引起UCP-2的表達(dá)增加,其可能在OSAS所致糖代謝異常的發(fā)生、發(fā)展中起橋梁作用。
[Abstract]:Objective: to observe the abnormal glucose metabolism in patients with obstructive sleep apnea hypopnea syndrome (OSAS) and the changes of serum uncoupling protein-2 (UCP-2), and to explore the possible mechanism of abnormal glucose metabolism in patients with obstructive sleep apnea hypopnea syndrome (OSAS). Methods: 31 patients with OSAS were divided into mild and moderate group (16 cases) and severe group (15 cases). 14 patients with OSAS complicated with type 2 diabetes mellitus, 14 patients with type 2 diabetes mellitus and 18 patients with simple obesity were selected. There was no significant difference in age and sex among groups. Height and weight were measured and body mass index (BMI) was calculated. All the subjects were monitored with PSG through night polysomnography. The sleep apnea hypopnea index (AHI) and the lowest nocturnal oxygen saturation (LSAO _ 2) were obtained. The fasting venous blood samples were collected at 7: 00 the next morning to determine the levels of HbA1cG, FBG and UCP-2, and to compare the differences of all the test indexes among the groups, and to analyze the correlation between the two groups. The result is 1: 1. Compared with the obese control group, the levels of HbA1C in the other groups were significantly higher than those in the obese control group, and the difference was statistically significant (P 0.05). Severe OSAS group, combined group, diabetes group and mild to moderate OSAS group, the increase was more significant, the difference was statistically significant (P 0.05). In the combined group and the diabetes group, the increase was more obvious than that in the severe group (P 0.05). There was no significant difference between the combined group and the diabetic group. 2. The levels of UCP-2 in diabetic group, severe OSAS group and combined group were significantly higher than those in control group and mild to moderate group (P 0.05). Compared with diabetes mellitus group and severe group, the combined group was significantly higher than that of the severe group (P 0.05). There was no significant difference between mild and moderate group and control group. There was no significant difference between severe group and diabetes group. 3. Correlation analysis showed that there was a positive correlation between UCP-2 level and AHIHbA1cFPG, and a negative correlation between UCP-2 level and LSO2. Conclusion 1. There is abnormal glucose metabolism in patients with OSAS, and it is related to the severity of OSAS. 2.OSAS can increase the expression of UCP-2, which may play a bridge role in the pathogenesis and development of glucose metabolism abnormality induced by OSAS.
【學(xué)位授予單位】：山西醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2012
【分類號(hào)】：R766

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