本文選題：阻塞性睡眠呼吸暫停低通氣綜合征 + 骨質(zhì)疏松　； 參考：《中國(guó)骨質(zhì)疏松雜志》2017年09期

【摘要】：目的通過(guò)測(cè)定阻塞性睡眠呼吸暫停低通氣綜合征(obstructive sleep apnea hypopnea syndrome,OSAHS)患者骨密度及血清骨保護(hù)素(osteoprotegerin,OPG)、核因子κB受體活化因子配體(receptor activator of nuclear factor kappa-B ligand,RANKL)的變化,初步探討OSAHS與骨質(zhì)疏松的關(guān)系。方法根據(jù)呼吸暫停低通氣指數(shù)(apnea hypopnea index,AHI)將我院確診的88名OSAHS患者分為3組:輕度組(5次/h≤AHI15次/h)30例、中度組(15次/h≤AHI30次/h)30例、重度組(AHI≥30次/h)28例,并選擇30名健康人群作為正常對(duì)照組。記錄所有受試者一般資料,測(cè)定骨代謝指標(biāo)及腰椎、股骨頸骨密度,采用雙抗體夾心酶聯(lián)免疫吸附法檢測(cè)各組受試者的血清OPG、RANKL水平,比較各組之間的差異并與AHI進(jìn)行相關(guān)性分析,P0.05為差異有統(tǒng)計(jì)學(xué)意義。結(jié)果中度OSAHS組腰椎、股骨頸骨密度較正常對(duì)照組降低,差異有統(tǒng)計(jì)學(xué)意義;重度OSAHS組腰椎、股骨頸骨密度分別較正常對(duì)照組、輕度OSAHS組降低,差異有統(tǒng)計(jì)學(xué)意義。各組OSAHS患者血清OPG均較正常對(duì)照組降低,其中重度OSAHS組分別與輕度OSAHS組、正常對(duì)照組差異有統(tǒng)計(jì)學(xué)意義。各組OSAHS患者血清RNAKL均較正常對(duì)照組升高,其中中度OSAHS組較正常對(duì)照組差異有統(tǒng)計(jì)學(xué)意義,重度OSAHS組分別較輕度OSAHS組、正常對(duì)照組差異有統(tǒng)計(jì)學(xué)意義。Pearson相關(guān)性分析結(jié)果顯示:骨密度、OPG與AHI呈負(fù)相關(guān),RANKL與AHI呈正相關(guān)。結(jié)論OSAHS患者有發(fā)生骨質(zhì)疏松的風(fēng)險(xiǎn),且與缺氧程度密切相關(guān),OPG/RANKL比率下調(diào)可能為作用機(jī)制之一。
[Abstract]:Objective to determine the changes of bone mineral density (BMD) in patients with obstructive sleep apnea hypopnea syndrome (OSAHS) and the changes of serum osteoprotegerin OPG, nuclear factor- 魏 B receptor activator ligand receptor activator of nuclear factor kappa-B ligand (RANKL) in patients with obstructive sleep apnea hypopnea syndrome (OSAHS), and to explore the relationship between OSAHS and osteoporosis. Methods according to apnea hypopnea index, 88 patients with OSAHS in our hospital were divided into 3 groups: 30 cases of mild group with 5 / h 鈮，

本文編號(hào)：1945253