本文選題：荷丹片 + 阿托伐他汀��； 參考：《中國醫(yī)藥導報》2016年03期

【摘要】：目的探討荷丹片聯(lián)合阿托伐他汀對伴有睡眠呼吸暫停的腦梗死患者血脂及炎癥因子的影響。方法依據(jù)多導睡眠圖檢測結果選取2013年1月~2015年6月于河北大學附屬醫(yī)院就診的74例伴有睡眠呼吸暫停的腦梗死患者作為研究對象,隨機分為對照組和觀察組,兩組均為37例,對照組給予口服阿托伐他汀,觀察組給予口服荷丹片聯(lián)合阿托伐他汀,兩組患者均給藥4周,觀察治療前后血清三酰甘油(TG)、總膽固醇(TC)、低密度脂蛋白膽固醇(LDL-C)、超敏C反應蛋白(hs-CRP)及可溶性細胞間黏附分子1(s ICAM-1)的變化情況。結果觀察組及對照組患者治療后血清TG[(2.549±0.441)、(2.854±0.444)mmol/L]、TC[(2.865±1.035)、(2.992±0.991)mmol/L]、LDL-C[(1.778±0.486)、(1.827±0.527)mmol/L]、hs-CRP[(1.846±0.607)、(2.230±0.799)mg/L]及s ICAM-1[(315.532±39.717)、(345.108±30.733)ng/m L]水平均較治療前[(3.630±0.548)、(3.862±0.683)mmol/L;(5.878±0.999)、(5.757±1.062)mmol/L;(3.687±0.581)、(3.538±0.658)mmol/L;(4.500±1.432)、(4.422±1.540)mg/L;(397.762±33.752)、(409.243±39.001)ng/m L]顯著降低,差異有高度統(tǒng)計學意義(P0.01)。兩組治療后TC、LDL-C水平比較差異無統(tǒng)計學意義(P0.05),但觀察組治療后TG、hs-CRP及s ICAM-1水平顯著低于對照組,差異有統(tǒng)計學意義(P0.05或P0.01)。結論荷丹片聯(lián)合阿托伐他汀對伴有睡眠呼吸暫停的腦梗死患者有較強的降脂作用,尤其是降TG方面,且增強抗炎作用。
[Abstract]:Objective to investigate the effects of Hedan tablets combined with Atto vastatin on blood lipid and inflammatory factors in patients with cerebral infarction with sleep apnea. Methods according to the results of polysomnography, 74 patients with cerebral infarction with sleep apnea were randomly divided into control group and observation group from January 2013 to June 2015. The control group was given Atto vastatin and the observation group was treated with Hedan tablet combined with Atto vastatin for 4 weeks. The changes of serum triacylglycerol (TGG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), hypersensitive C-reactive protein (hs-CRP) and soluble intercellular adhesion molecule (ICAM-1) were observed before and after treatment. 緇撴灉瑙傚療緇勫強瀵圭収緇勬?zhèn)ｈ�呮不鐤楀悗琛，

本文編號：1941331