本文選題：阻塞性睡眠呼吸暫停低通氣 + 血流變��； 參考：《實用醫(yī)學雜志》2016年16期

【摘要】：目的:檢測阻塞性睡眠呼吸暫停低通氣綜合征(OSAHS)患者血流變及血栓前標志物水平的變化,探討OSAHS患者并發(fā)心腦血管血栓栓塞性疾病的可能機制。方法:選取經(jīng)多導睡眠監(jiān)測儀監(jiān)測診斷的86例OSAHS患者,分為輕度組、中度組、重度組。選取20例健康者為正常對照組。檢測各組間血流變指標及血栓前標志物水平并進行相關(guān)分析。結(jié)果:輕、中及重度OSAHS組患者全血粘度、紅細胞聚集指數(shù)、紅細胞電泳時間均高于正常對照組。不同程度OSAHS組患者血流變指標差異有統(tǒng)計學意義,且全血粘度、紅細胞聚集指數(shù)、紅細胞電泳時間隨OSAHS程度加重而升高。OSAHS患者血漿粘度與正常對照組比較差異無統(tǒng)計學意義。OSAHS患者血漿中D-D、AT-Ⅲ、v WF的水平與正常對照組比較差異無統(tǒng)計學意義。結(jié)論:OSAHS患者存在血粘度、紅細胞聚集升高、紅細胞電泳時間延長等血流變異常改變,可能是OSAHS患者心腦血管血栓栓塞性疾病發(fā)生率增加的原因之一。
[Abstract]:Objective: to investigate the changes of hemorheology and prethrombotic markers in patients with obstructive sleep apnea hypopnea syndrome (OSAHS) and to explore the possible mechanism of cardiovascular and cerebrovascular thromboembolism in patients with OSAHS. Methods: 86 patients with OSAHS diagnosed by polysomnography were divided into mild group, moderate group and severe group. 20 healthy subjects were selected as normal control group. Blood rheological indexes and prethrombotic markers were measured and analyzed. Results: the whole blood viscosity, erythrocyte aggregation index and erythrocyte electrophoresis time of mild, moderate and severe OSAHS patients were higher than those of normal control group. There were significant differences in hemorheological indexes among patients with different degrees of OSAHS, and the whole blood viscosity, erythrocyte aggregation index, Erythrocyte electrophoresis time increased with the aggravation of OSAHS. There was no significant difference in plasma viscosity between patients with OSAHS and normal controls. There was no significant difference in plasma D-DX AT- 鈪，

本文編號：1931589