發(fā)布時(shí)間：2018-05-23 20:45

  本文選題：阻塞性睡眠呼吸暫停綜合征 + 間歇缺氧　； 參考：《中國(guó)現(xiàn)代醫(yī)學(xué)雜志》2017年13期

【摘要】：目的通過(guò)復(fù)制阻塞性睡眠呼吸暫停綜合征(OSAHS)的間歇缺氧(IH)大鼠模型,觀察IH對(duì)大鼠心肌氧化應(yīng)激的損傷及其復(fù)氧后的變化情況。方法 40只SD大鼠隨機(jī)分為4組,對(duì)照組(A組)10只,復(fù)制30只阻塞性睡眠呼吸暫停綜合征的間歇缺氧大鼠模型,其中10只缺氧組(B組),10只缺氧后復(fù)氧組(C組),另外10只持續(xù)缺氧組(D組)。檢測(cè)各組大鼠血清中丙二醛(MDA)含量和超氧化物歧化酶(SOD)活性,以及心肌組織中還原型谷胱甘肽(GSH)活性。結(jié)果與對(duì)照組大鼠比較,IH模型大鼠MDA含量增高,SOD活性降低,心肌組織GSH活性降低,差異具有統(tǒng)計(jì)學(xué)意義(P0.05);復(fù)氧組大鼠MDA、SOD和心肌組織GSH活性恢復(fù)正常,差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05);而D組大鼠MDA含量增高,SOD活性降低,心肌組織GSH活性降低,差異具有統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論 OSAHS存在氧化應(yīng)激,嚴(yán)重?fù)p傷心肌組織,缺氧時(shí)MDA含量、SOD和GSH活性改變,復(fù)氧后有所恢復(fù)。血清MDA含量、SOD活性及心肌組織GSH活性可以反應(yīng)氧化應(yīng)激的嚴(yán)重程度。
[Abstract]:Objective to investigate the myocardial oxidative stress and its changes after reoxygenation in rats with obstructive sleep apnea syndrome (OSAHS) induced by intermittent hypoxic hypoxia (IH) in rats with obstructive sleep apnea syndrome (OSAHS). Methods Forty Sprague-Dawley rats were randomly divided into four groups: control group (n = 10) and control group (n = 10). Thirty rats with obstructive sleep apnea syndrome (OSAS) were induced by intermittent hypoxia. There were 10 rats in group B and 10 rats in group C after hypoxia reoxygenation, and 10 rats in group D of continuous hypoxia. The content of malondialdehyde (MDA), the activity of superoxide dismutase (SOD) and the activity of glutathione (GSH) in myocardium were measured. Results compared with the control group, the activity of MDA increased and the activity of GSH in myocardial tissue decreased, the difference was statistically significant (P 0.05), the activity of MDA-SOD and the activity of GSH in myocardium returned to normal in reoxygenation group. There was no significant difference (P 0.05), but in group D, the activity of MDA increased and the activity of GSH in myocardium decreased. The difference was statistically significant (P 0.05). Conclusion there are oxidative stress in OSAHS and serious injury to myocardial tissue. The content of MDA and the activity of GSH are changed during hypoxia and recover after reoxygenation. The level of serum MDA and the activity of GSH in myocardium can reflect the severity of oxidative stress.
【作者單位】： 黔南民族醫(yī)學(xué)高等�？茖W(xué)校生理教研室;黔南民族醫(yī)學(xué)高等�？茖W(xué)校病理學(xué)教研室;貴州醫(yī)科大學(xué)第三附屬醫(yī)院老年科;
【分類號(hào)】：R-332;R766

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