本文選題：OASHS + 高血壓��； 參考：《中國地方病防治雜志》2017年02期

【摘要】：目的分析OSAHS合并高血壓血管內(nèi)皮功能與交感神經(jīng)活性的作用。方法打鼾患者115例依照血壓測定、多導(dǎo)睡眠檢測情況分為單純OSAHS組(O組,39例),單純高血壓組(H組,35例),OSAHA合并高高血壓組(OH組,41例),另外選本院同期健康體檢人員無打鼾者50例作為對照組,測定睡眠前后患者血壓、交感神經(jīng)活性及血管內(nèi)皮因子。結(jié)果O、OH組minSaO_2均顯著低于對照組(P0.05),AHI顯著高于H組和對照組(P0.05)。H、OH組睡前血壓均顯著高于對照組和O組(P0.05)。O、OH組睡眠NE水平顯著高于睡眠前(P0.05)。醒后O、OH組內(nèi)皮素均升高,NO下降,對照組和H組醒后內(nèi)皮素下降,NO升高。O組NE與MDA正相關(guān),醒后MAP與AHI、氧減指數(shù)、T90正相關(guān),與minSaO_2負相關(guān)。NE與睡眠呼吸紊亂負相關(guān),OH組內(nèi)皮素與NP負相關(guān)。結(jié)論 OSAHS病情與交感神經(jīng)活性增強有關(guān)。
[Abstract]:Objective to analyze the role of vascular endothelial function and sympathetic nerve activity in patients with OSAHS complicated with hypertension. Methods 115 patients with snoring were measured according to blood pressure. The polysomnography was divided into OSAHS group (n = 39), hypertension group (n = 35) and high hypertension group (n = 41). In addition, 50 healthy persons without snoring were selected as control group. Blood pressure, sympathetic nerve activity and vascular endothelial factor were measured before and after sleep. Results the minSaO_2 of the OOOOH group was significantly lower than that of the control group (P0.05AHI), which was significantly higher than that of the control group and the control group (P0.05AHI). The blood pressure before bedtime in the OOOH group was significantly higher than that in the control group and O group (P 0.05). The sleep NE level in the OOOH group was significantly higher than that in the control group (P 0.05). The levels of endothelin increased and no decreased in OFOH group after waking, while the level of endothelin in control group and H group increased after waking. NE and MDA were positively correlated in group O. MAP was positively correlated with AHI and oxygen reduction index (T90) after waking. There was a negative correlation between endothelin and NP in OH group. Conclusion the condition of OSAHS is related to the enhancement of sympathetic nerve activity.
【作者單位】： 衡水市哈勵遜國際和平醫(yī)院職業(yè)健康查體科;
【基金】：衡水市科技局科研基金立項項目(編號:14004A)
【分類號】：R544.1;R766

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