本文選題：自發(fā)熒光 + 周邊部　； 參考：《山西醫(yī)科大學(xué)》2012年碩士論文

【摘要】：目的觀察周邊部視網(wǎng)膜格子樣變性區(qū)的脂褐質(zhì)相關(guān)自發(fā)熒光(FAF)和黑色素相關(guān)自發(fā)熒光(NIA)特征,通過FAF和NIA研究格子樣變性區(qū)視網(wǎng)膜功能與代謝的改變。 方法50例視網(wǎng)膜格子樣變性患者68只眼納入本研究。所有患者均經(jīng)裂隙燈前置鏡眼底檢查及歐堡全景眼底照相系統(tǒng)(Optomap200)確診。應(yīng)用共焦激光眼底血管造影儀HRA2(海德堡視網(wǎng)膜脈絡(luò)膜眼底造影系統(tǒng))行脂褐質(zhì)相關(guān)自發(fā)熒光(FAF)及黑色素相關(guān)近紅外光自發(fā)熒光(NIA)檢查。通過將格子樣變性區(qū)與周圍正常視網(wǎng)膜組織的自發(fā)熒光(AF)強(qiáng)度進(jìn)行比較,把AF強(qiáng)度分級為強(qiáng)熒光、正常熒光、弱熒光和無熒光。對照眼底全景照相結(jié)果歸納總結(jié)視網(wǎng)膜格子樣變性的FAF及NIA特征,并將這兩種AF表現(xiàn)特征進(jìn)行對比分析。 結(jié)果68只眼中,FAF顯示有異常熒光表現(xiàn)有68只眼,占100%。表現(xiàn)為與格子樣變性區(qū)形態(tài)一致的邊界清晰的強(qiáng)熒光者12只眼,占17.6%；表現(xiàn)為與格子樣變性區(qū)形態(tài)一致的邊界清晰的強(qiáng)熒光中間雜斑片狀弱熒光及無熒光者56只眼,占82.4%。NIA顯示有異常熒光表現(xiàn)有57只眼,占83.8%。表現(xiàn)為大致正常熒光者11只眼,占16.2%；表現(xiàn)為與格子樣變性區(qū)形態(tài)一致的邊界尚清的稍強(qiáng)熒光中間雜斑片狀弱熒光及無熒光者16只眼,占23.5%；表現(xiàn)為邊界不清的稍強(qiáng)熒光中間雜斑片狀弱熒光或無熒光者41只眼,占60.3%。兩種自發(fā)熒光對比分析顯示：FAF所示強(qiáng)熒光強(qiáng)度比NIA更強(qiáng)；FAF與NIA所示斑片狀弱熒光位置及大小一致；FAF所示格子樣變性區(qū)的邊界較NIA更為清晰。 結(jié)論HRA2可清晰獲取周邊部視網(wǎng)膜格子樣變性區(qū)自發(fā)熒光圖像。視網(wǎng)膜格子樣變性區(qū)有其特征性的自發(fā)熒光表現(xiàn)。格子樣變性與RPE細(xì)胞內(nèi)脂褐質(zhì)的積聚有關(guān),與RPE細(xì)胞內(nèi)黑色素之間的關(guān)系不明顯。
[Abstract]:Objective to observe the characteristics of lipofuscin associated autofluorescence (FAF) and melanin-associated autofluorescence (NIA) in the latticular degeneration of the peripheral retina, and to investigate the changes of retinal function and metabolism by FAF and NIA. Methods Sixty-eight eyes of 50 patients with retinal lattice degeneration were included in this study. All patients were diagnosed by slit lamp anterior ophthalmoscopy and Optomap200 panoramic fundus photography system. HRA2 (Heidelberg Retinal choroidal fundus Angiography system) was used to detect lipofuscin associated autofluorescence (FAF) and melanin related near infrared autofluorescence (NIAA). The intensity of AF was classified as strong fluorescence, normal fluorescence, weak fluorescence and no fluorescence by comparing the AFI intensity of the lattice denatured area with that of the surrounding normal retina. The FAF and NIA features of retinal latticular degeneration were summarized and compared with the results of panoramic radiography. Results 68 eyes showed abnormal fluorescence in 68 eyes, accounting for 100%. There were 12 eyes (17.6 eyes) with strong fluorescence with clear boundary consistent with the shape of the lattice denatured area, 56 eyes with weak and non-fluorescent heteroplakia with clear boundary and clear boundary with the shape of the denatured area. 82.4%.NIA showed abnormal fluorescence in 57 eyes (83.8%). There were 11 eyes with approximately normal fluorescence, accounting for 16.2%, and 16 eyes with slight strong fluorescence with clear boundary and 16 eyes with no fluorescence. There were 41 eyes (60.3%) with weak or no fluorescence in the middle of slightly strong fluorescence with unclear boundary. The contrast analysis of two kinds of autofluorescence shows that the strong fluorescence intensity of NIA is stronger than that of NIA, and the boundary of the lattice denatured region shown by FFAF is more clear than that of NIA. Conclusion HRA2 can obtain the autofluorescence images of the peripheral retinal lattice degeneration clearly. The latticular degeneration of the retina has its characteristic autofluorescence features. Lattice degeneration was related to the accumulation of lipofuscin in RPE cells, but not to melanin in RPE cells.
【學(xué)位授予單位】：山西醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2012
【分類號】：R774.1

【參考文獻(xiàn)】

相關(guān)期刊論文 前1條

1 高紅;;視網(wǎng)膜變性的熒光血管造影檢查觀察[J];醫(yī)藥論壇雜志;2007年14期

，

本文編號：1848083