本文選題：青光眼 + 房水��； 參考：《眼科》2017年04期

【摘要】：目的比較急、慢性原發(fā)性閉角型青光眼與老年性白內(nèi)障患者房水中多種炎癥因子濃度的差異。設計實驗研究。研究對象連續(xù)的16例急性閉角型青光眼患者、16例慢性閉角型青光眼患者、22例老年性白內(nèi)障患者的房水。方法使用懸浮液相芯片技術同時檢測房水中多種細胞因子濃度,比較不同組之間的差異,并進行細胞因子間相關性分析。顯著水準0.0167。主要指標房水中粒細胞集落刺激因子(G-CSF)、干擾素-γ(IFN-γ)、白介素-6(IL-6)、白介素-8(IL-8)、單核細胞趨化蛋白-1(MCP-1),血小板衍生生長因子-AA(PDGF-AA)、血小板衍生生長因子-AB(PDGF-AB)、趨化因子配體5(RANTES)、腫瘤壞死因子-α(NF-α)的濃度。結(jié)果急性閉角型青光眼患者房水中G-CSF、PDGF-AA、IL-6、IL-8、MCP-1、RANTES和TNF-α濃度均顯著高于白內(nèi)障組(P均0.0167),慢性閉角型青光眼患者房水中G-CSF、PDGF-AA、IL-6、IL-8和MCP-1濃度顯著高于白內(nèi)障組(P均0.0167),急性和慢性閉角型青光眼房水中各炎癥因子濃度均無統(tǒng)計學差異(P均0.0167)。結(jié)論除了急性閉角型青光眼外,慢性閉角型青光眼眼前節(jié)也存在炎癥反應。
[Abstract]:Objective to compare the concentration of multiple inflammatory factors in aqueous humor of patients with acute, chronic primary angle closure glaucoma and senile cataract. Design experimental research. Participants Sixteen consecutive patients with acute angle-closure glaucoma 16 patients with chronic angle-closure glaucoma and 22 patients with senile cataract had aqueous humor. Methods the concentration of cytokines in aqueous humor was detected simultaneously by suspension liquid chip technique. The differences among different groups were compared and the correlation between cytokines was analyzed. Significant level 0.0167. Main outcome measures concentration of granulocyte colony stimulating factor G-CSFN, IFN- 緯 -interferon- 緯, interleukin-6 (IL-6), interleukin-8 (IL-8), monocyte chemotactic protein (MCP-1), platelet-derived growth factor (AAAN) PDGF-AAN, platelet-derived growth factor-ABPDGF-ABN, chemokine ligand 5ARANTESU, tumor necrosis factor- 偽 NF- 偽 in aqueous humor. Results the concentrations of G-CSFU PDGF-AAIL-6 IL-8 and TNF- 偽 in aqueous humor of patients with acute angle-closure glaucoma were significantly higher than those in cataract group (P = 0.0167), and those in aqueous humor of patients with chronic angle-closure glaucoma were significantly higher than those in cataract group (P = 0.0167). There was no statistical difference in the concentration of inflammatory factors in aqueous humor of light eyes (P = 0.0167). Conclusion in addition to acute angle-closure glaucoma, there are inflammatory reactions in the anterior segment of chronic angle-closure glaucoma.
【作者單位】： 第三軍醫(yī)大學大坪醫(yī)院野戰(zhàn)外科研究所眼科 重慶市眼科學重點實驗室;
【分類號】：R775.2;R776.1

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