本文選題：青光眼 + 房水��； 參考：《眼科》2017年04期

【摘要】：目的比較急、慢性原發(fā)性閉角型青光眼與老年性白內(nèi)障患者房水中多種炎癥因子濃度的差異。設(shè)計實驗研究。研究對象連續(xù)的16例急性閉角型青光眼患者、16例慢性閉角型青光眼患者、22例老年性白內(nèi)障患者的房水。方法使用懸浮液相芯片技術(shù)同時檢測房水中多種細(xì)胞因子濃度,比較不同組之間的差異,并進(jìn)行細(xì)胞因子間相關(guān)性分析。顯著水準(zhǔn)0.0167。主要指標(biāo)房水中粒細(xì)胞集落刺激因子(G-CSF)、干擾素-γ(IFN-γ)、白介素-6(IL-6)、白介素-8(IL-8)、單核細(xì)胞趨化蛋白-1(MCP-1),血小板衍生生長因子-AA(PDGF-AA)、血小板衍生生長因子-AB(PDGF-AB)、趨化因子配體5(RANTES)、腫瘤壞死因子-α(NF-α)的濃度。結(jié)果急性閉角型青光眼患者房水中G-CSF、PDGF-AA、IL-6、IL-8、MCP-1、RANTES和TNF-α濃度均顯著高于白內(nèi)障組(P均0.0167),慢性閉角型青光眼患者房水中G-CSF、PDGF-AA、IL-6、IL-8和MCP-1濃度顯著高于白內(nèi)障組(P均0.0167),急性和慢性閉角型青光眼房水中各炎癥因子濃度均無統(tǒng)計學(xué)差異(P均0.0167)。結(jié)論除了急性閉角型青光眼外,慢性閉角型青光眼眼前節(jié)也存在炎癥反應(yīng)。
[Abstract]:Objective to compare the concentration of multiple inflammatory factors in aqueous humor of patients with acute, chronic primary angle closure glaucoma and senile cataract. Design experimental research. Participants Sixteen consecutive patients with acute angle-closure glaucoma 16 patients with chronic angle-closure glaucoma and 22 patients with senile cataract had aqueous humor. Methods the concentration of cytokines in aqueous humor was detected simultaneously by suspension liquid chip technique. The differences among different groups were compared and the correlation between cytokines was analyzed. Significant level 0.0167. Main outcome measures concentration of granulocyte colony stimulating factor G-CSFN, IFN- 緯 -interferon- 緯, interleukin-6 (IL-6), interleukin-8 (IL-8), monocyte chemotactic protein (MCP-1), platelet-derived growth factor (AAAN) PDGF-AAN, platelet-derived growth factor-ABPDGF-ABN, chemokine ligand 5ARANTESU, tumor necrosis factor- 偽 NF- 偽 in aqueous humor. Results the concentrations of G-CSFU PDGF-AAIL-6 IL-8 and TNF- 偽 in aqueous humor of patients with acute angle-closure glaucoma were significantly higher than those in cataract group (P = 0.0167), and those in aqueous humor of patients with chronic angle-closure glaucoma were significantly higher than those in cataract group (P = 0.0167). There was no statistical difference in the concentration of inflammatory factors in aqueous humor of light eyes (P = 0.0167). Conclusion in addition to acute angle-closure glaucoma, there are inflammatory reactions in the anterior segment of chronic angle-closure glaucoma.
【作者單位】： 第三軍醫(yī)大學(xué)大坪醫(yī)院野戰(zhàn)外科研究所眼科 重慶市眼科學(xué)重點實驗室;
【分類號】：R775.2;R776.1

【相似文獻(xiàn)】

相關(guān)期刊論文 前2條

1 謝明捷;呂紅彬;何躍;趙春會;;炎癥因子與糖尿病視網(wǎng)膜病變相關(guān)性研究進(jìn)展[J];眼科新進(jìn)展;2012年10期

2 牛紅麗;馬利軍;王海播;況紅艷;;OSAHS合并高血壓患者血清炎癥因子濃度與血壓的關(guān)系[J];中國實用醫(yī)藥;2008年30期

相關(guān)會議論文 前1條

1 楊萍;;辛伐他汀對糖尿病視網(wǎng)膜病變和炎癥因子的影響[A];中華醫(yī)學(xué)會第十二次全國內(nèi)分泌學(xué)學(xué)術(shù)會議論文匯編[C];2013年

相關(guān)碩士學(xué)位論文 前1條

1 陳靜;炎癥因子在糖尿病視網(wǎng)膜病變中的作用研究[D];昆明醫(yī)科大學(xué);2016年

，

本文編號：1813566