本文選題：阻塞性睡眠呼吸暫停低通氣綜合征 + 肺動(dòng)脈高壓��； 參考：《中國呼吸與危重監(jiān)護(hù)雜志》2016年03期

【摘要】：目的探討血清腫瘤壞死因子α(TNF-α)、白細(xì)胞介素6(IL-6)、C反應(yīng)蛋白(CRP)與阻塞性睡眠呼吸暫停低通氣綜合征(OSAHS)相關(guān)肺動(dòng)脈高壓(PH)的關(guān)系。方法收集寧夏醫(yī)科大學(xué)總醫(yī)院2013年9月至2014年10月OSAHS患者38例及OSAHS相關(guān)PH患者32例,健康對(duì)照組35例。采用多導(dǎo)睡眠監(jiān)測儀診斷OSAHS,超聲心動(dòng)圖測量肺動(dòng)脈收縮壓(PASP),以PASP≥40 mm Hg為PH標(biāo)準(zhǔn),酶聯(lián)免疫吸附法檢測血清TNF-α、IL-6、CRP及內(nèi)皮素1(ET-1)水平。結(jié)果三組人群血清TNF-α、IL-6、CRP、ET-1水平差異有統(tǒng)計(jì)學(xué)意義(F=55.34、25.05、23.85、34.06,P0.05),兩兩比較發(fā)現(xiàn)OSAHS組各因子水平高于健康對(duì)照組(P0.05),OSAHS相關(guān)PH組各因子水平高于健康對(duì)照組及OSAHS組(P0.05);PASP與四項(xiàng)炎性因子均呈正相關(guān)關(guān)系(r=0.755、0.762、0.747、0.759,均P0.01)。結(jié)論血清TNF-α、IL-6、CRP水平與OSAHS相關(guān)PH有相關(guān)性,提示這類炎性因子參與了OSAHS相關(guān)PH的形成。
[Abstract]:Objective to investigate the relationship between serum tumor necrosis factor- 偽 (TNF- 偽), interleukin-6 (IL-6) -C-reactive protein (CRP) and pulmonary hypertension associated with obstructive sleep apnea hypopnea syndrome (OSAHS). Methods from September 2013 to October 2014, 38 patients with OSAHS, 32 patients with OSAHS associated PH and 35 healthy controls were collected from the General Hospital of Ningxia Medical University. OSAHS was diagnosed by polysomnography, pulmonary arterial systolic blood pressure (PASP) was measured by echocardiography, serum TNF- 偽 IL-6 CRP and endothelin 1 (ET-1) were measured by enzyme-linked immunosorbent assay (Elisa) with PASP 鈮，

本文編號(hào)：1810447