本文選題：鼻阻塞 + 大鼠�。� 參考：《山東大學(xué)》2017年碩士論文

【摘要】：目的本研究通過建立生長發(fā)育期鼻阻塞的Wistar大鼠模型,評價(jià)基于Micro-CT數(shù)據(jù)的上氣道形態(tài)學(xué)和流體力學(xué)變化,為分析生長發(fā)育期鼻阻塞狀態(tài)下上氣道變化提供理論依據(jù)。材料和方法選取三周齡的雄性Wistar大鼠20只,隨機(jī)分為兩組:A組:對照組、B組:雙側(cè)鼻阻塞組,每組各10只。用特制阻塞器間歇性完全阻塞大鼠雙側(cè)外鼻,阻塞時(shí)間為8:00am至4:00pm,即每天連續(xù)阻塞8小時(shí)。49天后Wistar大鼠麻醉固定于仰臥位,攝取頭頸部 Micro-CT(Skyscan1076:Skyscan,Antwerp,Belgium)數(shù)據(jù)。用MIMICS17.0對攝取的上氣道數(shù)據(jù)進(jìn)行三維重建,并利用ANSYS16.0軟件對氣道內(nèi)流場特征進(jìn)行仿真模擬。采用SPSS19.0軟件進(jìn)行對照組與實(shí)驗(yàn)組上氣道三維形態(tài)及流場特征變化的配對t檢驗(yàn)分析,檢驗(yàn)標(biāo)準(zhǔn)設(shè)P0.05。對上氣道的氣流阻力(R)與上氣道的形態(tài)學(xué)參數(shù)(體積V、平均橫截面積Smean、氣道一致性Smin/Smean)的相關(guān)關(guān)系進(jìn)行皮爾森相關(guān)性檢驗(yàn)(Pearson correlation analyze)分析。結(jié)果間歇性雙側(cè)完全鼻阻塞組的上氣道體積及平均橫截面積較對照組明顯減小,其中氣道體積及平均橫截面積變化最顯著的部位在口咽處,且此處的形態(tài)一致性Smin/Smean明顯差于對照組。上氣道流場特征的數(shù)值模擬顯示,氣流最大負(fù)壓在喉部而氣流最大壓降及最高流速處均在口咽。實(shí)驗(yàn)組的壓降和氣流流速較對照組明顯增大,變化最明顯處也在口咽。該處的壓降變化與體積、平均橫截面積和形態(tài)一致性變化呈負(fù)相關(guān)關(guān)系。結(jié)論生長發(fā)育期的鼻阻塞使上氣道狹窄,口咽部位最明顯,通氣功能明顯降低。
[Abstract]:Objective to evaluate the changes of upper airway morphology and fluid mechanics based on Micro-CT data by establishing a Wistar rat model of the growth and development of nasal obstruction, and to provide a theoretical basis for the analysis of the upper airway changes during the growth and development of nasal obstruction. 20 male Wistar rats of three weeks old were randomly divided into two groups: A group: The control group, B group: bilateral nasal obstruction group, each group of 10. With the special blocker intermittently completely obstruct the rat bilateral outer nose, the blocking time is 8:00am to 4:00pm, that is, every day after 8 hours of obstruction, Wistar rats are fixed at the supine position, and the Micro-CT (Skyscan1076:Skyscan, Antwerp, Belgium) data of the head and neck are taken. MIMICS17.0 is used. The data of the upper airway was reconstructed, and the characteristics of the flow field in the airway were simulated by ANSYS16.0 software. The paired t test was used to analyze the three-dimensional shape and flow characteristics of the upper airway in the control group and the experimental group by the SPSS19.0 software, and the test standard set up the morphological parameters of the air flow resistance (R) and the upper airway of the upper gas channel by the standard P0.05.. The correlation of number (volume V, mean cross section area Smean, airway conformance Smin/Smean) was analyzed by Pearson correlation test (Pearson correlation analyze). Results the upper airway volume and average cross section area of intermittent bilateral complete nasal obstruction group were significantly smaller than those of the control group. The changes in the volume and average cross section area of the airway were the most significant. In the oropharynx, the shape consistency of the Smin/Smean is significantly worse than that in the control group. The numerical simulation of the flow field in the upper airway shows that the maximum pressure drop in the throat and the maximum flow pressure drop and the maximum flow velocity are all in the oropharynx. The pressure drop and the flow velocity of the experimental group are significantly higher than those of the control group, and the most obvious change is also in the oropharynx. There was a negative correlation between the pressure drop and the volume, the average cross section area and the shape consistency. Conclusion the nasal obstruction caused the upper airway stenosis, the most obvious oropharynx, and the ventilation function decreased.

【學(xué)位授予單位】：山東大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R766;R782

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