本文選題：早產(chǎn)兒視網(wǎng)膜病變 + 眼底相機��； 參考：《南京航空航天大學》2017年碩士論文

【摘要】：正確觀察并獲取視網(wǎng)膜周邊區(qū)域圖像,可為早產(chǎn)兒視網(wǎng)膜病變(ROP)等多種眼科疾病的早期檢測提供客觀依據(jù)。傳統(tǒng)眼底相機由于成像視場較小,需要患者高度配合,難以獲取視網(wǎng)膜周邊區(qū)域圖像,無法應(yīng)用于ROP等眼疾的早期檢測。廣域數(shù)字眼底成像系統(tǒng)可以觀察視網(wǎng)膜周邊區(qū)域并對其成像,為ROP等眼疾的早期檢測和治療提供更好的幫助。論文將重點研究便攜式的廣域數(shù)字眼底成像系統(tǒng)及其關(guān)鍵技術(shù),為廣域眼底數(shù)字成像系統(tǒng)的研制提供理論依據(jù)和實踐指導。本論文主要研究內(nèi)容如下:1.根據(jù)ROP等眼疾檢測的要求,提出并研制了一種采用角膜接觸透鏡和環(huán)形分布光纖照明的便攜式廣域眼底成像系統(tǒng),將廣域眼底成像系統(tǒng)與Android終端通過WiFi傳輸模塊相結(jié)合,廣域眼底成像系統(tǒng)通過Android終端控制即可完成眼底圖像的快速、實時采集,為ROP等眼疾提供客觀的診斷依據(jù)。2.為模擬廣域眼底成像系統(tǒng)的真實使用環(huán)境,根據(jù)人眼結(jié)構(gòu)和各屈光介質(zhì)光學參數(shù)建立了LIOU人眼模型。對人眼組織光譜特性和安全保護標準以及眼底相機工作原理進行研究,提出采用近紅外光源作為成像系統(tǒng)的觀察調(diào)焦光源,可見光作為成像系統(tǒng)的成像光源。3.根據(jù)理想物像關(guān)系建立了視場為45°的眼底正常視場成像光路,確定了成像光路的結(jié)構(gòu)參數(shù)。通過分析計算得到采用同時移動成像物鏡和圖像探測器的調(diào)焦方式對不同屈光度(-10D~10D)人眼成像的調(diào)焦曲線圖,在ZEMAX中模擬并分析了基于LIOU人眼模型的正常視場成像光路,可實現(xiàn)不同屈光度人眼的清晰成像。4.在正常成像視場光路的基礎(chǔ)上引入非球面凹凸角膜接觸透鏡和環(huán)形光纖照明的方法實現(xiàn)視場為90°的眼底廣域成像與照明,分析并解決了影響眼底廣域成像的主要因素。使用ZEMAX和Lighttools分別對眼底廣域成像與照明進行了模擬與分析,結(jié)果表明廣域眼底成像系統(tǒng)滿足使用要求。5.在Android SDK和索尼相機API的基礎(chǔ)上完成了Android端視網(wǎng)膜成像系統(tǒng)軟件的開發(fā),將廣域眼底成像系統(tǒng)與Android終端相結(jié)合搭建了一套便攜式的視網(wǎng)膜成像系統(tǒng),最終實現(xiàn)了便攜式廣域數(shù)字眼底成像系統(tǒng)。
[Abstract]:The correct observation and acquisition of peripheral retinal images can provide an objective basis for the early detection of various ophthalmic diseases such as retinopathy of preterm infants. Because of the small field of view, the traditional fundus camera needs the high cooperation of patients, so it is difficult to obtain the image of peripheral retinal area, and can not be used in the early detection of eye diseases such as ROP. Wide-area digital fundus imaging system can observe and image the peripheral area of the retina, and provide better help for the early detection and treatment of eye diseases such as ROP. This paper focuses on the portable wide-area digital fundus imaging system and its key technology to provide theoretical basis and practical guidance for the development of wide-area digital fundus imaging system. The main contents of this thesis are as follows: 1. According to the requirements of ROP and other ophthalmopathy detection, a portable wide-area fundus imaging system using corneal contact lens and ring distributed optical fiber illumination is proposed and developed. The wide-area fundus imaging system is combined with the Android terminal through the WiFi transmission module. The wide area fundus imaging system can complete the fast and real-time acquisition of fundus images through Android terminal control, and provide objective diagnostic basis for ROP and other eye diseases. In order to simulate the real operating environment of wide-area fundus imaging system, the LIOU human eye model was established according to the human eye structure and the optical parameters of various refractive media. The spectral characteristics and safety protection standards of human eye tissue and the working principle of fundus camera are studied. The near infrared light source is used as the observation focusing source of the imaging system, and the visible light source is used as the imaging light source of the imaging system. Based on the ideal image relationship, a normal field of view imaging light path with a field of view of 45 擄is established, and the structural parameters of the imaging light path are determined. By analyzing and calculating, the focusing curves of different diopters are obtained by using simultaneous moving objective lens and image detector. The normal field of view imaging light path based on LIOU human eye model is simulated and analyzed in ZEMAX. The clear imaging of human eyes with different diopters can be realized. 4. On the basis of normal field of view light path, the method of aspherical concave convex contact lens and annular optical fiber illumination is introduced to realize the wide area imaging and illumination of the eye ground with the field of view of 90 擄. The main factors affecting the wide area imaging of the eye ground are analyzed and solved. The wide-area imaging and illumination were simulated and analyzed by ZEMAX and Lighttools, respectively. The results show that the wide-area imaging system meets the requirement of .5. On the basis of Android SDK and Sony camera API, the software of Android retinal imaging system is developed. A portable retinal imaging system is built by combining wide-area fundus imaging system with Android terminal. Finally, the portable wide area digital fundus imaging system is realized.
【學位授予單位】：南京航空航天大學
【學位級別】：碩士
【學位授予年份】：2017
【分類號】：R770.4;TP311.52

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