本文選題：青少年結(jié)膜痣　切入點：結(jié)膜惡性黑色素瘤　出處：《臨床與實驗病理學(xué)雜志》2017年03期

【摘要】：目的探討青少年結(jié)膜痣(juvenile conjunctival nevus,JCN)的臨床病理學(xué)特征及免疫表型、診斷及鑒別診斷。方法對12例JCN進行光鏡觀察及免疫組化EnVision兩步法染色,并復(fù)習(xí)相關(guān)文獻(xiàn)。結(jié)果 12例患者平均年齡15.5歲,在眼球結(jié)膜、淚阜和角結(jié)膜緣可見色素性斑塊。鏡下均為復(fù)合痣,非黏附性痣細(xì)胞團融合性生長,且缺乏皮膚痣常見的成熟現(xiàn)象。痣細(xì)胞多為上皮樣,大小形態(tài)較一致,整個病變中缺乏核分裂象和壞死。免疫表型:HMB-45陽性主要表達(dá)于交界區(qū)和黏膜固有層上部,Ki-67增殖指數(shù)2%~4%。結(jié)論 JCN是特殊部位發(fā)生的良性痣細(xì)胞增生性病變,需與結(jié)膜惡性黑色素瘤鑒別,臨床資料、組織學(xué)改變、免疫表型及基因檢測對鑒別診斷均具有重要作用。
[Abstract]:Objective to investigate the clinicopathological features, immunophenotype, diagnosis and differential diagnosis of juvenile conjunctival nevusus.Methods 12 cases of JCN were observed by light microscope and immunohistochemical EnVision two-step staining, and the related literatures were reviewed.Results the mean age of 12 patients was 15.5 years old, and pigmented plaques were seen in conjunctiva, lacrimal caruncle and Cortex conjunctiva.All of them were compound nevus under microscope. The cells of non-adherent nevus grew fused and lacked the common maturation of skin nevus.The nevus cells were mostly epithelioid, uniform in size and size, lacking mitotic and necrotic features in the whole lesion.The immunophenotype of HMB-45 was mainly expressed in the junctional area and the upper lamina propria of mucous membrane.Conclusion JCN is a benign proliferative lesion of nevus, which should be distinguished from conjunctival malignant melanoma. Clinical data, histological changes, immunophenotype and gene detection are important for differential diagnosis.
【作者單位】： 湖南省吉首大學(xué)第一附屬醫(yī)院病理科;
【分類號】：R777.3

【相似文獻(xiàn)】

相關(guān)期刊論文 前4條

1 紀(jì)元,鄭邦和,李遼青;球結(jié)膜痣的電鏡觀察一例[J];眼科研究;1989年02期

2 郭征;結(jié)膜痣冷凍治療后惡變?yōu)楹谏亓?例[J];實用眼科雜志;1990年12期

3 熊有正, 陳振謙;CO＿2激光消除眼結(jié)膜痣斑[J];實用美容整形外科;1994年02期

4 ;[J];;年期

，

本文編號：1730546