本文選題：髓過氧化物酶　切入點：肝細胞生長因子　出處：《臨床耳鼻咽喉頭頸外科雜志》2017年11期

【摘要】：目的:探討OSAHS患者外周血干細胞生長因子(HGF)、髓過氧化物酶(MPO)的表達及意義。方法:通過PSG確診的96例OSAHS患者為OSAHS組,根據AHI范圍分為重、中、輕3組;32例于我科體檢健康者為對照組;ELISA法測定血HGF、MPO水平;予以重度OSAHS患者手術+CPAP方案治療3個月并復測體內HGF、MPO濃度,分析HGF、MPO和PSG指標的相關性。結果:(1)隨著OSAHS病情程度增加,其外周血HGF和MPO濃度逐漸上升,不同程度各組患者HGF、MPO不全相同(F=119.006,25.138;P0.01);其中輕度組與對照組間無明顯差別(P0.05);其余各組相互比較均有明顯差別(P0.05)。(2)OSAHS患者血HGF、MPO濃度和年齡、BMI無關(P0.05),而HGF與MPO濃度改變呈正相關,且二者均與AHI呈正相關,與LSaO2呈負相關(P0.05)。(3)32例重度OSAHS患者經過3個月綜合方案治療后LSaO2上升,AHI、外周血HGF、MPO水平降低,均有明顯差別(P0.01)。治療6個月后MPO、HGF濃度較治療3個月時降低(P0.05),但和對照組相比仍有升高(P0.05)。結論:手術聯(lián)合較長時程CPAP治療可降低OSAHS患者缺氧程度,降低心血管損害,其療效和療程相關;聯(lián)合測定OSAHS患者外周血HGF與MPO對病情、療效的判斷及并發(fā)心血管損害的評估有一定的臨床參考價值。
[Abstract]:Objective: to investigate the expression and significance of peripheral blood stem cell growth factor (OSAHS) in patients with OSAHS. Methods: 96 patients with OSAHS diagnosed by PSG were divided into two groups: OSAHS group according to the range of AHI. The serum levels of HGF MPO were measured by Elisa in 32 healthy subjects in our department, and the levels of HGFG MPO in patients with severe OSAHS were measured by CPAP regimen for 3 months. The correlation between MPO and PSG was analyzed. Results: with the increase of the severity of OSAHS, the HGF and MPO concentrations in peripheral blood increased gradually. There was no significant difference between mild group and control group (P 0.05), and there was significant difference between other groups (P 0.05). There was no significant correlation between HGF and MPO. Both of them were positively correlated with AHI, and negatively correlated with LSaO2 in 32 patients with severe OSAHS. After 3 months of comprehensive treatment, LSaO2 increased and the level of MPO in peripheral blood decreased. After 6 months of treatment, the concentration of MPOG was lower than that at 3 months, but it was still higher than that of the control group. Conclusion: operation combined with long-term CPAP treatment can reduce the degree of hypoxia and cardiovascular damage in patients with OSAHS. The combined determination of HGF and MPO in peripheral blood of patients with OSAHS has a certain clinical reference value in the evaluation of disease, curative effect and cardiovascular damage.
【作者單位】： 廣州醫(yī)科大學附屬第二醫(yī)院耳鼻咽喉科;
【分類號】：R766
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本文編號：1694249