發(fā)布時間：2018-03-13 10:37

  本文選題：慢性鼻竇炎　切入點：克拉霉素　出處：《中國藥房》2017年30期 　論文類型：期刊論文

【摘要】：目的:探討克拉霉素強化治療用于慢性鼻竇炎患者的療效、安全性及對血清炎性細胞因子的影響。方法:186例慢性鼻竇炎患者隨機分為對照1組(62例)、對照2組(62例)和觀察組(62例)。對照1組患者口服阿莫西林克拉維酸鉀片(7∶1)0.457 g,每日3次;對照2組患者口服克拉霉素分散片0.25 g,每日1次;觀察組患者口服克拉霉素分散片第1周0.5 g,每日2次,第2周0.25g,每日2次。各組患者療程均為2周。觀察各組患者的臨床療效和治療前后各臨床癥狀評分、腫瘤壞死因子α(TNF-α)、白細胞介素6(IL-6)、超敏C反應(yīng)蛋白(hs-CRP)水平及不良反應(yīng)發(fā)生情況。結(jié)果:總有效率觀察組(93.55%)對照2組(80.65%)對照1組(65.51%),差異均有統(tǒng)計學(xué)意義(P0.05)。治療前,各組患者各臨床癥狀評分、TNF-α、IL-6、hs-CRP水平比較,差異均無統(tǒng)計學(xué)意義(P0.05);治療后,各組患者各臨床癥狀評分、TNF-α、IL-6、hs-CRP水平均顯著低于同組治療前,且觀察組對照2組對照1組,差異均有統(tǒng)計學(xué)意義(P0.05)。觀察組、對照2組患者不良反應(yīng)發(fā)生率均顯著低于對照1組,差異均有統(tǒng)計學(xué)意義(P0.05),但觀察組與對照2組間比較,差異無統(tǒng)計學(xué)意義(P0.05)。結(jié)論:克拉霉素強化治療用于慢性鼻竇炎的療效顯著,可改善患者的臨床癥狀,降低血清炎性細胞因子水平,且未增加不良反應(yīng)的發(fā)生。
[Abstract]:Objective: to investigate the curative effect of clarithromycin intensive therapy in patients with chronic sinusitis. Methods 186 patients with chronic sinusitis were randomly divided into control group (n = 62) and control group (n = 62) and observation group (n = 62) and control group (n = 62). 7: 1: 0.457 g, 3 times a day; Patients in the control group were given clarithromycin dispersible tablets 0.25 g once a day, while those in the observation group received 0.5 g clarithromycin dispersible tablets once a day twice a day. The second week was 0.25 g, twice a day. The course of treatment was 2 weeks. The clinical efficacy and clinical symptom scores before and after treatment were observed. The levels of TNF- 偽, IL-6, hs-CRP and the occurrence of adverse reactions. Results: the total effective rate in observation group was 93.55) and the control group was 80.65) the difference was statistically significant before treatment. After treatment, the levels of TNF- 偽 and IL-6 hs-CRP in each group were significantly lower than those before treatment, and the levels of TNF- 偽 and IL-6 hs-CRP in the observation group were significantly lower than those in the control group, and there was no significant difference in the levels of TNF- 偽 and IL-6hs-CRP between the two groups after treatment, and there was no significant difference in the levels of TNF- 偽 and IL-6hs-CRP between the two groups after treatment. The incidence of adverse reactions in the observation group and the control group was significantly lower than that in the control group (P 0.05), but there was a significant difference between the observation group and the control group. Conclusion: clarithromycin intensive therapy for chronic sinusitis can improve the clinical symptoms, reduce the level of serum inflammatory cytokines, and does not increase the occurrence of adverse reactions.
【作者單位】： 南陽市中心醫(yī)院靜脈用藥調(diào)配中心;南陽市中心醫(yī)院耳鼻喉科;
【分類號】：R765.41
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本文編號：1606018