發(fā)布時(shí)間：2018-03-02 18:15

  本文選題：喉腫瘤　切入點(diǎn)：癌胚抗原　出處：《臨床耳鼻咽喉頭頸外科雜志》2017年15期 　論文類型：期刊論文

【摘要】：目的:探討喉癌患者血清中癌胚抗原(CEA),細(xì)胞角蛋白片段21-1(Cyfra21-1),鱗狀細(xì)胞癌抗原(SCC)與喉癌各臨床病理指標(biāo)的關(guān)系及意義。方法:選取喉癌手術(shù)患者53例,術(shù)前常規(guī)檢測血清CEA、Cyfra21-1、SCC,統(tǒng)計(jì)分析其與喉癌患者的年齡、原發(fā)灶(T分期)、淋巴結(jié)轉(zhuǎn)移(N分期)、復(fù)發(fā)轉(zhuǎn)移等臨床指標(biāo)的關(guān)系。結(jié)果:患者按年齡≤60歲與60歲、有淋巴結(jié)轉(zhuǎn)移與無淋巴結(jié)轉(zhuǎn)移、有無復(fù)發(fā)轉(zhuǎn)移、T1+T2與T3+T4進(jìn)行分組,進(jìn)行兩樣本均數(shù)t檢驗(yàn),結(jié)果表明:CEA與患者復(fù)發(fā)轉(zhuǎn)移的關(guān)系有統(tǒng)計(jì)學(xué)意義(P=0.047),CEA升高時(shí)提示更容易復(fù)發(fā)或轉(zhuǎn)移,CEA與患者的原發(fā)灶(P=0.252)、淋巴結(jié)轉(zhuǎn)移(P=0.268)的關(guān)系無統(tǒng)計(jì)學(xué)意義;Cyfra21-1與原發(fā)灶的關(guān)系無統(tǒng)計(jì)學(xué)意義(P=0.402),與淋巴結(jié)轉(zhuǎn)移的關(guān)系有統(tǒng)計(jì)學(xué)意義(P=0.041),淋巴結(jié)轉(zhuǎn)移時(shí)Cyfra21-1升高,與術(shù)后復(fù)發(fā)轉(zhuǎn)移有統(tǒng)計(jì)學(xué)意義(P=0.027),Cyfra21-1升高時(shí)提示更容易復(fù)發(fā)或轉(zhuǎn)移;SCC與原發(fā)灶的關(guān)系無統(tǒng)計(jì)學(xué)意義(P=0.051),與淋巴結(jié)轉(zhuǎn)移的關(guān)系有統(tǒng)計(jì)學(xué)意義(P=0.022),淋巴結(jié)轉(zhuǎn)移時(shí)SCC升高,與術(shù)后復(fù)發(fā)轉(zhuǎn)移有顯著統(tǒng)計(jì)學(xué)意義(P=0.000),SCC升高時(shí)提示更容易復(fù)發(fā)或轉(zhuǎn)移。Logistic多因素回歸分析結(jié)果:CEA、Cyfra21-1、SCC與患者術(shù)后復(fù)發(fā)的關(guān)系均有統(tǒng)計(jì)學(xué)意義(P0.05),而與患者的年齡、原發(fā)灶、淋巴結(jié)轉(zhuǎn)移的關(guān)系均無統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論:喉癌血清Cyfra21-1、SCC升高提示患者更容易出現(xiàn)淋巴結(jié)轉(zhuǎn)移及術(shù)后復(fù)發(fā)轉(zhuǎn)移,CEA、Cyfra21-1、SCC是患者術(shù)后復(fù)發(fā)轉(zhuǎn)移的獨(dú)立預(yù)知因子,術(shù)前CEA、Cyfra21-1、SCC值升高提示患者術(shù)后更容易出現(xiàn)復(fù)發(fā)及轉(zhuǎn)移。
[Abstract]:Objective: to investigate the relationship between carcinoembryonic antigen (CEA), cytokeratin fragment 21-1Cyfra21-1and squamous cell carcinoma antigen (SCCC) and the clinicopathological parameters of laryngeal carcinoma. Methods: 53 patients with laryngeal carcinoma were selected. Preoperative routine detection of serum CEA Cyfra21-1 SCC was performed, and its relationship with age, primary T staging, lymph node metastasis, recurrence and metastasis of laryngeal carcinoma was statistically analyzed. Results: the patients were aged 鈮，

本文編號：1557625