本文關(guān)鍵詞： 布拉氏酵母菌 鹽酸左西替利嗪 鼻炎 變應(yīng)性 細(xì)胞因子 兒童　出處：《臨床耳鼻咽喉頭頸外科雜志》2017年21期 　論文類(lèi)型：期刊論文

【摘要】：目的:探討布拉氏酵母菌聯(lián)合鹽酸左西替利嗪治療小兒變應(yīng)性鼻炎(AR)的臨床療效及對(duì)血清干擾素-γ(IFN-γ)和IL-4水平的影響。方法 :90例患兒隨機(jī)分為觀(guān)察組與對(duì)照組,每組45例,對(duì)照組用鹽酸左西替利嗪滴劑(2~6歲,5ml/次;6歲,10ml/次;1次/d,口服)。觀(guān)察組在對(duì)照組基礎(chǔ)上聯(lián)合布拉氏酵母菌(3歲,0.25g/次,1次/d;3歲,0.25g/次,2次/d,口服)。4周為1個(gè)療程,并設(shè)30例為健康組。結(jié)果:2組治療前血清IFN-γ水平明顯低于健康組(P0.01),而IL-4水平明顯高于健康組(P0.01);治療后2組均有不同程度的上調(diào)IFN-γ及下調(diào)IL-4的水平,但以治療組的作用更明顯(P0.01)。觀(guān)察組臨床總有效率為91.11%,明顯高于對(duì)照組的68.89%(χ2=6.94,P0.01)。治療后,2組患兒各項(xiàng)癥狀積分均較治療前降低,但觀(guān)察組明顯低于對(duì)照組(P0.01)。治療后組間比較,觀(guān)察組明顯優(yōu)于對(duì)照組(P0.01)。結(jié)論:布拉氏酵母菌聯(lián)合鹽酸左西替利嗪口服溶液治療小兒AR有明顯的臨床療效,其作用機(jī)制可能與糾正紊亂的IFN-γ與IL-4有關(guān)。
[Abstract]:Objective: to investigate the clinical effect of Saccharomyces Brassicus combined with levosirizine hydrochloride in the treatment of allergic rhinitis in children and its effect on serum interferon- 緯 (IFN- 緯) and IL-4 levels. Methods: one hundred and ninety children were randomly divided into two groups: observation group (n = 45) and control group (n = 45). The control group was treated with levo-cetirizine hydrochloride drop of 5 ml / time 6 years old or 10 ml / d once a day. The observation group was treated with 0.25g / d of Saccharomyces brassicum at the age of 3 years and 0.25g / time for 2 / d, and was given a course of treatment for a period of 4 weeks, and the control group was given a course of treatment for a period of 4 weeks, and the control group was given a dose of 0.25g / d + 0.25g / time, and the control group was given a course of treatment for a period of 4 weeks. Results the level of serum IFN- 緯 was significantly lower than that of healthy group before treatment, while the level of IL-4 was significantly higher than that of healthy group P0.01.After treatment, the levels of IFN- 緯 and down-regulation of IL-4 were up-regulated and down-regulated in both groups. However, the effect of the treatment group was more obvious than that of the control group (P 0.01). The total clinical effective rate of the observation group was 91.11, which was significantly higher than that of the control group (68.89g / kg, 蠂 2 = 6.94, P 0.01). After treatment, the symptom scores of the two groups were lower than those of the control group (P 0.01), but that of the observation group was significantly lower than that of the control group (P 0.01). Conclusion: the observation group is superior to the control group (P 0.01). Conclusion: the treatment of infantile AR with Saccharomyces Brassicus combined with levatirizine hydrochloride has obvious clinical effect, and its mechanism may be related to correcting the disorder of IFN- 緯 and IL-4.
【作者單位】： 金華市婦幼保健院兒科;金華職業(yè)技術(shù)學(xué)院醫(yī)學(xué)院兒科;
【分類(lèi)號(hào)】：R765.21

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