本文關鍵詞： 翼狀胬肉 患病率 漢族和藏族 危險因素　出處：《北京協(xié)和醫(yī)學院》2016年博士論文　論文類型：學位論文

【摘要】：背景翼狀胬肉是結膜向角膜生長的三角楔形纖維血管組織,可引起眼部刺激癥狀甚至影響視力。其具體發(fā)病機制尚不明確,針對不同人群的橫斷面研究所報道的患病率及危險因素存在差異。翼狀胬肉具有合并惡性腫瘤的風險,且其手術治療復發(fā)率較高,因此預防就顯得尤為重要。對危險因素和保護因素越來越深入的了解使我們有望逐漸減少未來翼狀胬肉的發(fā)生。目的通過橫斷面研究分析青海省漢族和藏族翼狀胬肉的患病率及危險因素。方法本研究為2015年7月-8月進行的一項覆蓋青海省4個縣市的橫斷面研究,通過多階段分層抽樣法抽取一個能代表青海省人口的樣本,采集了人口學特征、生活方式、疾病史等信息,前節(jié)檢查在小瞳下采用手持裂隙燈進行。以logistic回歸模型分析潛在的獨立危險因素。結果4711名調查對象納入分析,漢族2594人(55.1%),藏族2117人(44.9%)。平均年齡44歲(8-83歲)。翼狀胬肉的總體患病率為8.3%(n=391),其中單眼受累者5.3%(n=248),雙眼受累者3.0%(n=143),30歲以上人群年齡性別調整患病率為8.7%。多因素分析顯示高齡(p＜0.001)、女性(p＜0.001)、出生于農村(p=0.02)、室外工作(p=0.001)、高血壓病史(p=0.046)、遠視(p=0.049)為翼狀胬肉的危險因素,而高學歷(趨勢p=0.003)為獨立保護因素；僅高BMI(趨勢p=0.013)是雙眼翼狀胬肉的危險因素。男性中高齡(p＜0.001)、室外工作(p＜0.001)、高血壓病史(p=0.01)為翼狀胬肉的危險因素,目前吸煙(p=0.02)為保護因素,而吸煙指數(shù)與翼狀胬肉不相關(趨勢p=0.15)。女性中高齡(p＜0.001)、出生地為農村(p＜0.001)為翼狀胬肉的危險因素,而高學歷(p=0.04)為保護因素。在農村居住10年以內的人群患翼狀胬肉的危險性和城鎮(zhèn)居民無統(tǒng)計學差異(p=0.072),而居住時間滿10年者患病風險顯著增加,但其OR值并未隨農村居住時間的延長而進一步上升。結論本研究分析了青海省藏族和漢族中翼狀胬肉的患病率和危險因素。高齡、女性、農村、室外工作為翼狀胬肉的危險因素,高學歷為保護因素,而高血壓病史及遠視可能與翼狀胬肉相關。多因素分析未發(fā)現(xiàn)漢族和藏族間患病率具有統(tǒng)計學差異。男性中高齡、室外工作及高血壓病史為危險因素,而目前吸煙為保護因素；女性中發(fā)現(xiàn)高齡、農村為危險因素,高學歷為保護因素。農村居住時間滿10年者患翼狀胬肉的風險增加,早期脫離危險因素可能更好地預防翼狀胬肉的發(fā)生。
[Abstract]:Background pterygium is a triangular wedge-shaped fibrous vascular tissue with conjunctival growth to cornea, which can cause ocular irritation and even affect visual acuity. The specific pathogenesis of pterygium is not clear. The prevalence and risk factors of pterygium were different in cross-sectional study of different population. Pterygium had the risk of complicated with malignant tumor, and the recurrence rate of surgical treatment was higher. Therefore, prevention is particularly important. More and more in-depth understanding of risk factors and protective factors will lead us to gradually reduce the occurrence of pterygium. Objective to analyze the pterygium of Han nationality and Tibetan nationality in Qinghai Province by cross-sectional study. The prevalence and risk factors of pterygium. Methods A cross-sectional study covering 4 counties and cities in Qinghai Province was conducted from July 2015 to August. A multi-stage stratified sampling method was used to select a sample representing the population of Qinghai Province, and the demographic characteristics, lifestyle, disease history and other information were collected. Logistic regression model was used to analyze the potential independent risk factors. Results 4711 subjects were included in the analysis. The average age was 44 years old and 8-83 years old. The overall prevalence rate of pterygium was 8.3%. Among them, the patients with monocular involvement were 5.3and the patients with binocular involvement were 3.0and 143respectively. The age and gender adjusted prevalence rate of the population over 30 years old was 8.7%. The multivariate analysis showed that the elderly patients (p < 0.001) and the females (P < 0.001) were born in rural areas (P < 0.02). The risk factors of pterygium were found in outdoor work, hypertension, hyperopia and hyperopia. Higher educational background (trend p0.003) was the independent protective factor. High BMI (trend p0.013) was the risk factor of pterygium in both eyes. The history of hypertension (p0.01) is the risk factor of pterygium, and smoking is the protective factor. However, the smoking index was not correlated with pterygium (trend p0. 15). The elderly women (P < 0. 001) and the place of birth in the countryside (p < 0. 001) were the risk factors of pterygium. The risk of pterygium in the population living in rural areas less than 10 years was not significantly different from that of urban residents. However, there was a significant increase in the risk of disease among those who lived for more than 10 years. Conclusion the prevalence and risk factors of pterygium in Tibetan and Han nationality in Qinghai Province were analyzed. Outdoor work was the risk factor of pterygium, and higher education was the protective factor. The history of hypertension and hyperopia may be related to pterygium. There was no significant difference in prevalence rate between Han and Tibetan by multivariate analysis. Elderly men, outdoor work and hypertension history were risk factors. At present, smoking is the protective factor. The risk factors of pterygium were higher than 10 years, and the risk of pterygium was increased in women who lived in rural areas for more than 10 years. The risk factors of early detachment may be better to prevent the occurrence of pterygium.
【學位授予單位】：北京協(xié)和醫(yī)學院
【學位級別】：博士
【學位授予年份】：2016
【分類號】：R777.33

【相似文獻】

相關期刊論文 前10條

1 陸代鳳,張?zhí)靾?江熙;某電力局管理人員翼狀胬肉患病情況調查[J];中國職業(yè)醫(yī)學;2002年03期

2 常靜,田世元,白玉玲,魯占軍;翼狀胬肉根部切除術療效觀察[J];內蒙古民族大學學報(自然科學版);2002年06期

3 晉秀明,趙云娥,徐明;翼狀胬肉患者術前和術后淚液功能的臨床研究[J];眼科研究;2004年01期

4 劉玖明;翼狀胬肉驗案一則[J];實用中醫(yī)藥雜志;2004年05期

5 李軍;自體角膜緣干細胞移植治療翼狀胬肉121例遠期療效[J];衛(wèi)生職業(yè)教育;2005年15期

6 蔣洪帆;角膜緣干細胞移植術治療翼狀胬肉療效觀察[J];甘肅科技;2005年06期

7 梁君,王迎開,孫厚狀;沿海地區(qū)漁民翼狀胬肉發(fā)病的調查研究[J];國外醫(yī)學(物理醫(yī)學與康復學分冊);2005年03期

8 冉紅軍,肖健;翼狀胬肉撕脫術治療翼狀胬肉[J];眼外傷職業(yè)眼病雜志.附眼科手術;2005年10期

9 孫瑞芳;自體角膜緣干細胞移植治療翼狀胬肉療效觀察[J];眼外傷職業(yè)眼病雜志.附眼科手術;2005年10期

10 毛思紅,鄧文香,童毓華,劉凌;翼狀胬肉頭部撕離、角膜緣干細胞移植術聯(lián)合應用觀察[J];山東醫(yī)藥;2005年12期

相關會議論文 前10條

1 程玲;褚征宇;張宏娣;;翼狀胬肉撕脫術的治療[A];全省中西醫(yī)結合、中醫(yī)、西醫(yī)眼科學術交流會論文匯編[C];2006年

2 郭惠宇;徐燕妮;孫美鷗;;負載骨髓間充質干細胞羊膜片移植治療翼狀胬肉[A];中華醫(yī)學會第十二屆全國眼科學術大會論文匯編[C];2007年

3 劉曉燕;萬閩R，

本文編號：1488453