本文關(guān)鍵詞： 鼻炎 變應(yīng)性 季節(jié)性 匹多莫德 氯雷他定 炎癥趨化因子類 治療結(jié)果　出處：《中國全科醫(yī)學(xué)》2017年S2期 　論文類型：期刊論文

【摘要】：目的探討匹多莫德聯(lián)合氯雷他定治療小兒過敏性鼻炎的臨床療效及其對(duì)患兒炎性因子的影響。方法選取云南省第二人民醫(yī)院2014年3月—2016年3月收治的過敏性鼻炎患兒118例,按照隨機(jī)數(shù)字表法分為對(duì)照組和觀察組,各59例。對(duì)照組患兒采用氯雷他定等基礎(chǔ)治療,觀察組患兒在對(duì)照組基礎(chǔ)上加用匹多莫德治療,兩組患兒均持續(xù)治療4周。比較兩組患兒的臨床療效、臨床癥狀(鼻癢、流涕、鼻塞及打噴嚏)緩解時(shí)間、治療前后癥狀評(píng)分及炎性因子[白介素4(IL-4)、白介素5(IL-5)、白介素12(IL-12)及腫瘤壞死因子α(TNF-α)]水平。結(jié)果觀察組患兒治療總有效率高于對(duì)照組(P0.05)。觀察組患兒鼻癢、流涕、鼻塞、打噴嚏緩解時(shí)間短于對(duì)照組(P0.05)。治療前,兩組患兒鼻癢、流涕、鼻塞、打噴嚏評(píng)分比較,差異無統(tǒng)計(jì)學(xué)意義(P0.05);治療后,觀察組患兒鼻癢、流涕、鼻塞、打噴嚏評(píng)分低于對(duì)照組(P0.05)。治療前,兩組患兒IL-4、IL-5、IL-12及TNF-α水平比較,差異無統(tǒng)計(jì)學(xué)意義(P0.05);治療后,觀察組患兒IL-4、IL-5水平低于對(duì)照組,IL-12、TNF-α水平高于對(duì)照組(P0.05)。結(jié)論采用匹多莫德聯(lián)合氯雷他定治療小兒過敏性鼻炎的臨床療效確切,可有效改善患兒的臨床癥狀,降低炎性反應(yīng),促進(jìn)疾病恢復(fù)。
[Abstract]:Objective to investigate the clinical effect of pidomod combined with loratadine in the treatment of allergic rhinitis in children and its influence on inflammatory factors in children. Methods We selected the second people's Hospital of Yunnan Province from March 2014 to March 2016. 118 cases of allergic rhinitis were treated. According to the random number table method, the patients in the control group and the observation group were divided into two groups, 59 cases in each group. The children in the control group were treated with loratadine as basic therapy, and the children in the observation group were treated with pidomod on the basis of the control group. The clinical effects, clinical symptoms (nasal itch, runny nose, nasal congestion and sneezing), symptom scores and inflammatory factors were compared between the two groups for 4 weeks. [Interleukin-4 (IL-4) and IL-5 (IL-5). Results the total effective rate of treatment in the observation group was higher than that in the control group (P 0.05). Before treatment, the scores of itching, runny nose, nasal congestion and sneezing in the two groups were not significantly different (P 0.05). After treatment, the scores of nasal itch, runny nose, nasal congestion and sneeze in the observation group were lower than those in the control group (P 0.05). Before treatment, the levels of IL-4, IL-5, IL-12 and TNF- 偽 were compared between the two groups. The difference was not statistically significant (P 0.05). After treatment, the level of IL-4 and IL-5 in the observation group was lower than that in the control group. Conclusion the clinical effect of pidomod combined with loratadine in the treatment of allergic rhinitis in children is definite and can effectively improve the clinical symptoms of children with allergic rhinitis. Reduce inflammatory response and promote disease recovery.
【作者單位】： 云南省第二人民醫(yī)院耳鼻喉科;
【分類號(hào)】：R765.21
【正文快照】： 過敏性鼻炎是臨床較常見的一種過敏性疾病,發(fā)病率達(dá)10%~20%,好發(fā)于兒童。過敏性鼻炎病程較長(zhǎng),且易發(fā)作,主要臨床表現(xiàn)為鼻癢、打噴嚏等,易導(dǎo)致鼻竇炎、支氣管哮喘等并發(fā)癥[1-3],嚴(yán)重影響患兒的身心健康。相關(guān)研究表明,Th1/Th2細(xì)胞因子失衡與過敏性鼻炎關(guān)系密切,而匹多莫德對(duì)于T

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