發(fā)布時間：2018-12-09 08:05

【摘要】：目的觀察和比較右美托咪定和七氟醚對冠心病非心臟手術(shù)患者圍術(shù)期心肌保護的效應(yīng)。方法選擇擇期合并冠心病的腔鏡下胸腹部手術(shù)患者135例,男90例,女45例,年齡45~82歲,ASAⅡ或Ⅲ級。采用隨機數(shù)字表法將患者分為三組:對照組(C組),右美托咪定組(D組)和七氟醚組(S組),每組45例。采用依托咪酯0.2mg/kg、丙泊酚0.5mg/kg、順苯磺酸阿曲庫銨0.2~0.3mg/kg和芬太尼5.0~6.0μg/kg進行麻醉誘導和維持,D組誘導前10min開始至手術(shù)結(jié)束持續(xù)泵注右美托咪定。C組給予等容量生理鹽水。S組從麻醉誘導后開始持續(xù)吸入七氟醚至手術(shù)結(jié)束前30min停用。記錄術(shù)中和術(shù)后72h內(nèi)心肌缺血的發(fā)生情況。結(jié)果術(shù)中C組心肌缺血的發(fā)生率[12例(26.7%)]明顯高于D組[3例(6.7%)]和S組[4例(8.9%)](P0.05);術(shù)后72h內(nèi)C組、D組和S組心肌缺血的發(fā)生率分別為6例(13.3%)、4例(8.9%)和4例(8.9%),差異無統(tǒng)計學意義。結(jié)論右美托咪定和七氟醚均能通過改善心肌血氧供需平衡,降低冠心病非心臟手術(shù)患者心肌缺血的發(fā)生率。
[Abstract]:Objective to observe and compare the effects of dexmetidine and sevoflurane on perioperative myocardial protection in patients with coronary heart disease undergoing non-cardiac surgery. Methods one hundred and thirty-five patients (90 males and 45 females) with coronary heart disease (CHD) underwent endoscopic thoracoabdominal surgery (ASA 鈪，

本文編號：2369061