【摘要】：目的探討磁共振動(dòng)態(tài)增強(qiáng)(DCE)曲線類型及氫質(zhì)子波譜成像(~1H-MRS)對(duì)原發(fā)性骨肉瘤的應(yīng)用價(jià)值。資料與方法前瞻性納入41例符合研究標(biāo)準(zhǔn)的骨肉瘤患者,分別行DCE及~1H-MRS掃描,根據(jù)其病理結(jié)果分為高度和低度惡性骨肉瘤,利用分析軟件得到時(shí)間-信號(hào)強(qiáng)度曲線(TIC)并進(jìn)行分類;對(duì)其中18例~1H-MRS譜線穩(wěn)定的骨肉瘤患者進(jìn)行分析并得到Cho及Cho/Cr值,分別進(jìn)行統(tǒng)計(jì)分析。結(jié)果高度惡性骨肉瘤中TIC Ⅰ型、Ⅱ型曲線分別有20例、10例,低度惡性骨肉瘤TIC Ⅰ型、Ⅱ型、Ⅲ型曲線分別有2例、5例、4例,高、低度惡性骨肉瘤之間TIC類型分布差異有統(tǒng)計(jì)學(xué)意義(χ~2=10.876,P0.05)。高、低度惡性骨肉瘤的Cho/Cr值差異有統(tǒng)計(jì)學(xué)意義(Z=-2.445,P0.05)。以Cho/Cr作為診斷指標(biāo),最佳診斷界值為2.3。結(jié)論 TIC類型、Cho/Cr值對(duì)于評(píng)價(jià)骨肉瘤的惡性程度有一定的參考價(jià)值。
[Abstract]:Objective to investigate the type of dynamic enhanced (DCE) curve and the value of hydrogen proton spectrum imaging (~ 1H-MRS) in primary osteosarcoma. Materials and methods 41 patients with osteosarcoma who met the study criteria were included prospectively. DCE and ~ 1H-MRS scans were performed respectively. According to the pathological results, they were divided into high and low grade malignant osteosarcoma. The time-signal intensity curves (TIC) were obtained and classified by software, and the Cho and Cho/Cr values of 18 osteosarcoma patients with stable spectral line from 1H-MRS were analyzed and analyzed statistically. Results there were 20 cases of TIC type 鈪，

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