【摘要】：目的探討清蛋白、前清蛋白和C-反應蛋白檢測在普外科患者術后手術部位感染的診斷價值。方法選擇醫(yī)院2014年2月-2016年2月普外科手術患者320例,所有患者術前均確診無感染,分別于術后12、24h、3d和7d取血標本檢測清蛋白、前清蛋白和C-反應蛋白(CRP),監(jiān)測所有患者于術后7d內是否發(fā)生感染;根據(jù)診斷結果將患者分為感染組27例和未感染組293例,比較兩組術前、術后不同時間點的清蛋白、前清蛋白和CRP水平。結果術后發(fā)生感染患者27例,感染率8.44%,共檢出病原菌36株,其中革蘭陰性菌10株占27.78%,革蘭陽性菌16株占44.44%,真菌10株占27.78%;兩組患者清蛋白、前清蛋白、CRP在術前2h比較差異均無統(tǒng)計學意義,兩組術后12、24h、3d、7d感染組患者清蛋白、前清蛋白、CRP明顯低于術前,且感染組患者明顯低于未感染組(P0.05),兩組患者術后12、24h、3d、7dCRP均明顯高于術前2h,且感染組明顯高于對照組(P0.05);清蛋白、前清蛋白、CRP、清蛋白+前清蛋白、清蛋白+CRP、前清蛋白+CRP、清蛋白+前清蛋白+CRP 7種診斷方案對患者術后感染的診斷敏感度、特異度比較,以清蛋白+前清蛋白+CRP方案的診斷敏感度、特異度最佳。結論采用清蛋白+前清蛋白+CRP實驗數(shù)據(jù)診斷普外科患者術后手術部位感染,時效性和客觀性均較好,具有一定的臨床價值。
[Abstract]:Objective to investigate the diagnostic value of detection of albumin, prealbumin and C-reactive protein in postoperative surgical site infection of patients in general surgery. Methods 320 patients undergoing general surgery from February 2014 to February 2016 were selected. All the patients were diagnosed as having no infection before operation. Prealbumin and C-reactive protein (CRP), were used to monitor whether infection occurred in all the patients within 7 days after operation. According to the diagnosis, the patients were divided into infected group (n = 27) and uninfected group (n = 293). The serum albumin at different time points before operation and at different time points after operation were compared between the two groups. Prealbumin and CRP levels. Results there were 27 cases of postoperative infection, the infection rate was 8.44%. A total of 36 strains of pathogenic bacteria were detected, of which 10 strains were Gram-negative bacteria (27.78%), 16 strains were Gram-positive bacteria (44.44%), and 10 strains were fungi (27.78%). There was no significant difference in serum protein and protein levels between the two groups at 2 hours before operation. The levels of serum protein and protein of prealbumin were significantly lower in the two groups than those in the pre-operation group at 12: 24 hours after operation for 3 days and 7 days after operation, and no significant difference was found between the two groups. The CRP of the infection group was significantly higher than that of the control group (P0.05), and the CRP of the infection group was significantly higher than that of the control group (P0.05), and the CRP of the infection group was significantly higher than that of the control group (P0.05), and the CRP of the two groups was significantly higher than that of the control group (P0.05). The sensitivity and specificity of seven diagnostic protocols of albumin prealbumin (CRP) and prealbumin (CRP) for postoperative infection were compared. The diagnostic sensitivity and specificity of CRP regimen were the best. Conclusion using the CRP data of albumin prealbumin to diagnose postoperative infection of surgical site in patients with general surgery is of good timeliness and objectivity and has certain clinical value.
【作者單位】： 河南省南陽市中醫(yī)院外一科;
【分類號】：R619.3

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1 曲林林;丁連安;;清蛋白、前清蛋白和血清超敏C反應蛋白檢測對普外科病人術后感染的診斷意義[J];青島大學醫(yī)學院學報;2007年02期

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