本文選題：早期腸內(nèi)營養(yǎng) + 重型顱腦損傷��； 參考：《新鄉(xiāng)醫(yī)學院學報》2016年12期

【摘要】：目的探討早期腸內(nèi)營養(yǎng)對重型顱腦損傷患者免疫功能及并發(fā)癥的影響。方法選取2013年8月至2015年8月黃岡市中心醫(yī)院收治的重型顱腦損傷患者100例,其中50例患者給予早期腸外營養(yǎng)支持(對照組),50例患者于傷后12 h給予早期腸內(nèi)營養(yǎng)(觀察組);觀察并比較2組患者的免疫功能及并發(fā)癥發(fā)生情況。結果治療前2組患者血漿IgM、IgG、IgA和IgE水平比較差異均無統(tǒng)計學意義(P0.05)。對照組患者治療1周后血漿IgM、IgG、IgA水平顯著低于治療前(P0.05),IgE水平顯著高于治療前(P0.05)。觀察組患者治療1周后血漿IgM、IgG水平顯著低于治療前(P0.05),但治療前后血漿IgA、IgE水平比較差異無統(tǒng)計學意義(P0.05)。治療1周后,觀察組患者血漿中IgM、IgG、IgA水平顯著高于對照組(P0.05),IgE水平顯著低于對照組(P0.05)。治療前2組患者血漿中CD4~+、CD8~+水平、CD4~+/CD8~+比較差異均無統(tǒng)計學意義(P0.05)。治療1周后,2組患者CD4~+水平、CD4~+/CD8~+顯著高于治療前(P0.01),觀察組患者CD4~+水平、CD4~+/CD8~+顯著高于對照組(P0.05)。觀察組和對照組患者并發(fā)癥發(fā)生率分別為12.0%(6/50)和38.0%(19/50),觀察組患者并發(fā)癥發(fā)生率顯著低于對照組(P0.05)。結論早期腸內(nèi)營養(yǎng)可顯著改善重型顱腦損傷患者的免疫功能,降低并發(fā)癥發(fā)生率。
[Abstract]:Objective to investigate the effect of early enteral nutrition on immune function and complications in patients with severe craniocerebral injury. Methods from August 2013 to August 2015, 100 patients with severe craniocerebral injury were treated in Huanggang Central Hospital. 50 patients were treated with early parenteral nutrition (control group, 50 patients received early enteral nutrition 12 hours after injury), and the immune function and complications of the two groups were observed and compared. Results there was no significant difference in the levels of IgA and IgE between the two groups before treatment (P 0.05). After 1 week of treatment, the level of IgA in the control group was significantly lower than that in the control group (P 0.05), and the level of IgE in the control group was significantly higher than that in the control group (P 0.05). After 1 week treatment, the level of IgMN IgG in the observation group was significantly lower than that in the control group (P 0.05), but there was no significant difference between the two groups before and after treatment (P 0.05). After one week of treatment, the level of IgA in plasma of the patients in the observation group was significantly higher than that in the control group (P 0.05) and the level of IgE in the control group was significantly lower than that in the control group (P 0.05). There was no significant difference in plasma levels of CD4 ~ + / CD8- / CD8 ~ between the two groups before treatment (P 0.05). One week after treatment, the levels of CD4 ~ / CD8 ~ in the two groups were significantly higher than those in the control group (P 0.01), and the levels of CD _ 4 ~ / CD _ 8 ~ in the observation group were significantly higher than those in the control group (P 0.05). The incidence of complications in the observation group and the control group were 12.0 / 50 and 38.0 / 50 respectively. The incidence of complications in the observation group was significantly lower than that in the control group (P 0.05). Conclusion early enteral nutrition can significantly improve the immune function and reduce the incidence of complications in patients with severe craniocerebral injury.
【作者單位】： 黃岡市中心醫(yī)院神經(jīng)外科;
【分類號】：R651.15

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本文編號：1999521