本文選題：經(jīng)導管主動脈瓣植入術 + 主動脈瓣狹窄�。� 參考：《臨床心血管病雜志》2017年06期

【摘要】：目的:應用Meta分析的方法來評價經(jīng)導管主動脈瓣膜植入術(TAVI)治療二葉式主動脈瓣(BAV)重度狹窄的有效性及安全性。方法:通過計算機檢索建庫至2016年8月PubMed、The Cochrance Library、Embase、中國知網(wǎng)和萬方數(shù)據(jù)庫中發(fā)表的有關TAVI治療BAV重度狹窄的療效與安全性的前瞻性隊列研究。同時,手工檢索納入文獻的參考文獻,查找相關研究。篩選文獻、提取資料和評估納入研究的質量后,采用STATA12軟件進行薈萃分析。結果:納入5項前瞻性隊列研究,共2244例患者。NOS評分最高為8分,最低為7分,說明納入文獻質量較好。薈萃分析顯示:所繪制的漏斗圖顯示散點均勻分布于中線兩側,Begg及Egger檢驗顯示P值均0.05,提示各項研究無明顯發(fā)表偏倚。與非BVA狹窄組相比較,BAV狹窄組瓣膜置入成功率(RR1.019,95%CI0.982~1.057,P=0.327)、平均跨瓣壓差(SMD0.004,95%CI0.194~0.186,P=0.969)、30d死亡率(RR1.211,95%CI0.525~2.794,P=0.653)、30d復合終點事件發(fā)生率(RR1.096,95%CI0.684~1.757,P=0.703)、瓣周漏(≥2級)發(fā)生率(RR1.365,95%CI 0.959~1.943,P=0.084)、起搏器植入率(RR0.836,95%CI0.517~1.352,P=0.465)、嚴重血管并發(fā)癥發(fā)生率(RR1.085,95%CI 0.401~2.936,P=0.872)及致命性出血發(fā)生率(RR0.632,95%CI0.296~1.348,P=0.235)差異均無統(tǒng)計學意義。結論:對于不適合進行外科手術的BAV重度狹窄患者,TAVI是可行、安全和有效的。
[Abstract]:Objective: to evaluate the efficacy and safety of transcatheter aortic valve implantation (TAVI) in the treatment of severe two-lobe aortic valve stenosis by Meta analysis. Methods: a prospective cohort study on the efficacy and safety of TAVI in the treatment of severe BAV stenosis, published in the Cochrance Library Embase, China Zhiwang and Wanfang databases, was searched by computer until Aug. 2016. At the same time, manual retrieval into the literature references, to find relevant research. After screening the literature, extracting the data and evaluating the quality of the research, the meta-analysis was carried out with STATA12 software. Results: in 5 prospective cohort studies, 2244 patients had the highest score of 8 and the lowest of 7, indicating that the quality of the literature included was good. The meta-analysis showed that the scattered points were evenly distributed on both sides of the midline by the funnel diagram and the Egger test showed P value of 0.05, indicating that there was no obvious publication bias in all studies. 涓庨潪BVA鐙獎緇勭浉姣旇緝,BAV鐙獎緇勭摚鑶滅疆鍏ユ垚鍔熺巼(RR1.019,95%CI0.982~1.057,P=0.327),騫沖潎璺ㄧ摚鍘嬪樊(SMD0.004,95%CI0.194~0.186,P=0.969),30d姝諱骸鐜，

本文編號：1955562