本文選題：納米材料 + 羥基磷灰石�。� 參考：《北京化工大學(xué)》2016年碩士論文

【摘要】：骨組織損傷問題會(huì)給患者帶來很大困擾,嚴(yán)重的還會(huì)危及生命。人工骨修復(fù)材料是解決此類問題的重要途徑。仿骨材料則是其中一類用于模仿骨組織功能的骨修復(fù)替換材料。本論文從骨組織的組成羥基磷灰石和蛋白出發(fā),結(jié)合超重力技術(shù),探究了納米羥基磷灰石與蛋白/納米羥基磷灰石復(fù)合材料的制備過程及其在骨組織替換材料等生物醫(yī)學(xué)領(lǐng)域的應(yīng)用潛力。本文主要研究內(nèi)容如下：(1)本文使用不同磷源與鈣源制得納米羥基磷灰石(nHAP),并利用X射線衍射(XRD)、紅外光譜(FTIR)、透射電鏡(TEM)、熱重分析(TGA)等分析手段對(duì)產(chǎn)物進(jìn)行表征,探究不同反應(yīng)溫度,不同原料等實(shí)驗(yàn)條件對(duì)產(chǎn)物的組成、形貌、尺寸的影響。結(jié)果表明升高溫度有利于晶體成長,不同鈣源對(duì)產(chǎn)物影響不大,不同磷源對(duì)得到的產(chǎn)物組成影響較大,磷酸氫根會(huì)取代產(chǎn)物羥基磷灰石中的磷酸根,磷酸氫二鈉為原料的產(chǎn)物中磷酸氫根含量最高。(2)本文利用超重力沉淀法成功合成出nHAP,并通過XRD和TEM確定了晶體結(jié)構(gòu)與形態(tài),利用FTIR和電感耦合等離子體原子發(fā)射光譜(ICP-AES)分析了納米羥基磷灰石的化學(xué)性質(zhì)。表征結(jié)果表明合成的納米羥基磷灰石直徑為1.9-14.2 nm,長度為4.0-36.9 nm,并且與天然骨磷灰石類似,均為碳酸磷灰石結(jié)構(gòu)。另外,本文還對(duì)納米羥基磷灰石在制備磷酸鈣骨水泥(CPC)和明膠/HAP水凝膠復(fù)合材料方面的潛在應(yīng)用進(jìn)行了探討。(3)本文利用超重力共沉淀法制備了明膠蛋白/納米羥基磷灰石復(fù)合材料并采取多種測試手段表征了材料的理化性質(zhì)。結(jié)果證實(shí)了蛋白/HAP復(fù)合材料為納米棒狀晶型和具有高蛋白吸附率。此外,蛋白/HAP納米復(fù)合材料還被塑造成圓柱狀的CPC,測試結(jié)果表明平均抗壓模量為0.6 GPa,與人體松質(zhì)骨類似。同時(shí),利用此法也成功制備出絲蛋白/納米羥基磷灰石復(fù)合材料與CPC,表明此法具有一定的普適性。以上研究結(jié)果表明,本文提出的超重力技術(shù)結(jié)合化學(xué)沉淀法的路線具有很多優(yōu)勢,是一種能高效簡單、可產(chǎn)業(yè)化生產(chǎn)仿骨材料的新工藝。
[Abstract]:Bone tissue injury can cause great trouble and life-threatening for patients. Artificial bone repair material is an important way to solve this problem. Bone imitating material is a kind of bone repair replacement material used to imitate the function of bone tissue. In this paper, the composition of bone tissue hydroxyapatite and protein, combined with hypergravity technology, The preparation process of nano-hydroxyapatite / protein / nano-hydroxyapatite composite and its potential application in biomedical fields such as bone tissue replacement materials were investigated. The main contents of this paper are as follows: (1) Nano-hydroxyapatite (HAP) was prepared by using different phosphorus and calcium sources. The products were characterized by X-ray diffraction (XRD), FTIR (FTIR), TEM (Tem), TGA (thermogravimetric analysis) and so on. The effects of different reaction temperature, different raw materials and other experimental conditions on the composition, morphology and size of the product were investigated. The results show that increasing temperature is beneficial to crystal growth, different calcium sources have little effect on the product, and different phosphorus sources have great influence on the composition of the product. Hydrogen phosphate can replace the phosphate radical in the product hydroxyapatite. In this paper, nHAPs were synthesized by the method of hypergravity precipitation, and the crystal structure and morphology were determined by XRD and TEM. The chemical properties of nano-hydroxyapatite were analyzed by FTIR and ICP-AES-based inductively coupled plasma atomic emission spectrometry (ICP-AES). The results show that the synthesized nano-hydroxyapatite has a diameter of 1.9-14.2 nm and a length of 4.0-36.9 nm, which is similar to that of natural bone apatite. In addition, The potential applications of nano-hydroxyapatite in the preparation of calcium phosphate cement (CPC) and gelatin / HAP hydrogel composites were also discussed. The physical and chemical properties of the composites were characterized by various testing methods. The results show that protein / HAP composites are nanorods and have high protein adsorption rate. In addition, the protein / HAP nanocomposites were molded into cylindrical CPC.The results show that the average compressive modulus is 0.6 GPA, which is similar to that of human cancellous bone. At the same time, silk protein / nano-hydroxyapatite composites and CPC were successfully prepared by this method. The above results show that the proposed route of hypergravity combined with chemical precipitation has many advantages and is a new process for producing bone imitating material with high efficiency and simplicity.
【學(xué)位授予單位】：北京化工大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2016
【分類號(hào)】：R318.08;R68

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