發(fā)布時(shí)間：2018-04-29 06:15

  本文選題：腫瘤 + 乳腺癌　； 參考：《廣東醫(yī)學(xué)》2016年21期

【摘要】：目的分析青年女性乳腺癌晚期患者術(shù)后生存情況,為青年乳腺癌患者臨床治療和預(yù)測(cè)其預(yù)后提供參考依據(jù)。方法應(yīng)用Kaplan-Meier法、Log-rank檢驗(yàn)和Cox多元回歸模型分析入院治療的78例20~45歲青年女性乳腺癌晚期患者年齡、TNM分期、病理類型、術(shù)后化療方式與患者總體生存率的關(guān)系。結(jié)果 78例青年女性乳腺癌晚期患者1~5年總體生存率為84.28%、72.24%、65.36%、45.75%和45.75%。單因素分析結(jié)果表明,不同分組的總體生存率比較,TNMⅢ期患者高于Ⅳ期的晚期患者(X~2=15.123,P0.001);行化療規(guī)范方案的患者組高于化療不規(guī)則的患者(X~2=5.718,P=0.017);城區(qū)患者高于農(nóng)村地區(qū)患者(X~2=6.568,P=0.010);T1+T2期的患者組高于T3+T4期患者(X~2=5.062,P=0.024);尚未發(fā)現(xiàn)青年女性乳腺癌晚期患者的總體生存率與病理類型、年齡、腫瘤部位有統(tǒng)計(jì)學(xué)關(guān)聯(lián)(X~2=0.113、0.613、0.624,P=0.737、0.434、0.430);多因素Cox回歸模型分析結(jié)果表明,除診斷TNM高分期外,經(jīng)濟(jì)不發(fā)達(dá)的農(nóng)村地區(qū)(RR=3.146,95%CI=1.019~9.716,P=0.046)及不規(guī)則化療(RR=3.591,95%CI=1.169~11.033 5,P=0.026)是青年女性乳腺癌晚期患者總體生存率降低的獨(dú)立危險(xiǎn)因素。結(jié)論術(shù)后規(guī)范化療是青年女性乳腺癌晚期患者康復(fù)治療的有效手段,有利于提高患者生存率。
[Abstract]:Objective to analyze the postoperative survival of young female patients with advanced breast cancer and to provide reference for the clinical treatment and prognosis of young women with breast cancer. Methods the relationship between age, pathological type, postoperative chemotherapy and overall survival rate of 78 female patients with advanced breast cancer aged 20 to 45 years were analyzed by Kaplan-Meier method and Cox multivariate regression model. Results the overall 1 ~ 5 year survival rate of 78 young female patients with advanced breast cancer was 84.28% and 72.24% respectively. The total survival rate was 45.75% and 45.75% respectively. The results of single factor analysis show that, The overall survival rate of TNM 鈪，

本文編號(hào)：1818744