本文選題：椎間盤退變　切入點(diǎn)：丹酚酸B　出處：《揚(yáng)州大學(xué)學(xué)報(bào)(農(nóng)業(yè)與生命科學(xué)版)》2017年03期

【摘要】：使用針吸髓核法建立新西蘭大白兔的椎間盤退變模型,隨機(jī)分為8組,分別是A~E組。A組為單純骨髓間充質(zhì)干細(xì)胞(MSCs)移植組;B組為MSCs-丹酚酸B聯(lián)合治療組,包括B1、B2、B3、B4分別為1.25、2.50、5.00、10.00mg·L-14個(gè)亞組;C組為磷酸鹽緩沖液(PBS)移植組;D組為假移植組;E組為正常對(duì)照組。8周時(shí)處死動(dòng)物,分別采用半定量免疫組織化學(xué)法和間苯三酚法測(cè)定各組Ⅱ型膠原含量和椎間盤蛋白多糖含量,探討丹酚酸B聯(lián)合MSCs移植修復(fù)退變椎間盤的治療效果。結(jié)果表明:B3、B4組Ⅱ型膠原灰度值低于A組,Ⅱ型膠原含量和蛋白多糖含量均高于A組,差異顯著。說(shuō)明丹酚酸B濃度大于等于5.00mg·L~(-1)時(shí),丹酚酸B聯(lián)合干細(xì)胞移植的效果優(yōu)于單純干細(xì)胞移植組。
[Abstract]:The model of intervertebral disc degeneration in New Zealand white rabbits was established by needle aspiration of nucleus pulposus. The model was randomly divided into 8 groups: group A, group A, simple bone marrow mesenchymal stem cells (MSCs)) group B was treated with MSCs- Salvianolic acid B, and group B was treated with MSCs- Salvianolic acid B (MSCs- Salvianolic acid B).The content of type 鈪，

本文編號(hào)：1720191