本文選題：骨質(zhì)疏松　切入點：椎體壓縮骨折　出處：《中國骨質(zhì)疏松雜志》2017年03期 　論文類型：期刊論文

【摘要】：目的初步探討骨質(zhì)疏松性椎體壓縮骨折患者、骨質(zhì)疏松患者以及無骨質(zhì)疏松患者3者間椎體骨質(zhì)的差別。方法對30例需要進行手術治療的患者進行分組,分別為骨質(zhì)疏松性椎體壓縮骨折患者組、骨質(zhì)疏松患者組及無骨質(zhì)疏松患者組,每組10例。在術中分別取出3組患者少許椎體樣本,椎體樣本大小相等,不影響手術療效的同時亦不會對患者造成不良影響,患者均表示知情同意。隨后分別對取出的椎體標本進行顯微計算機斷層掃描術(micro-computed tomography,Micro-CT)檢測,以了解及對比3組患者之間椎體骨密度(bone mineral density,BMD)、骨礦含量(bone mineral content,BMC)和骨小梁情況。結(jié)果骨質(zhì)疏松性椎體壓縮骨折患者組對比骨質(zhì)疏松患者組、無骨質(zhì)疏松患者組其椎體皮質(zhì)骨BMD、松質(zhì)骨BMD、骨小梁BMD和總體BMD以及皮質(zhì)骨BMC、松質(zhì)骨BMC和總BMC均有明顯下降,差異具有統(tǒng)計學意義(P0.05),其中骨小梁BMD、皮質(zhì)骨BMC、松質(zhì)骨BMC和總BMC下降顯著(P0.01);骨質(zhì)疏松患者組對比無骨質(zhì)疏松患者組其椎體皮質(zhì)骨BMD、松質(zhì)骨BMD、骨小梁BMD和總體BMD以及皮質(zhì)骨BMC、松質(zhì)骨BMC和總BMC均有下降,差異具有統(tǒng)計學意義(P0.05),其中骨小梁BMD下降顯著(P0.01)。結(jié)論較低的椎體BMD和BMC是椎體壓縮骨折發(fā)生發(fā)展的主要原因,骨質(zhì)疏松患者和暫無骨質(zhì)疏松人群需要預防BMD、BMC的下降,防止骨質(zhì)疏松性椎體壓縮骨折的發(fā)生。
[Abstract]:Objective to explore the difference of vertebral bone in patients with osteoporotic vertebral compression fracture, osteoporosis and non-osteoporosis. Methods Thirty patients who need surgical treatment were divided into two groups. There were 10 cases in each group of patients with osteoporotic vertebral compression fracture, group with osteoporosis and group without osteoporosis. A few vertebral body samples were taken out from 3 groups of patients during operation, and the size of vertebral samples was equal. There was no adverse effect on the outcome of the operation and no adverse effect on the patients. The patients gave their informed consent. The vertebral specimens were then examined by micro-computed tomography (micro-computed tomography micro-CT). To understand and compare the bone mineral density, bone mineral content and bone trabeculae between the three groups, results the patients with osteoporotic vertebral compression fracture were compared with the osteoporosis group. The cortical bone, cancellous bone, trabecular bone BMD and total BMD, cortical bone BMC, cancellous bone BMC and total BMC were significantly decreased in the group without osteoporosis. The difference was statistically significant (P 0.05), in which trabecular bone, cortical bone, cancellous bone BMC and total BMC decreased significantly (P 0.01), and the vertebral cortical bone, cancellous bone, bone trabecular BMD and total BMD in the osteoporosis group were compared with those in the non-osteoporosis group. Cortical bone BMC, cancellous bone BMC and total BMC were all decreased. The difference was statistically significant (P 0.05), among which the decrease of bone trabecular BMD was significant (P 0.01). Conclusion low BMD and BMC are the main causes of vertebral compression fracture, and the patients with osteoporosis and those without osteoporosis need to prevent the decline of BMD-BMC. Prevent osteoporotic vertebral compression fracture.
【作者單位】： 廣州中醫(yī)藥大學;廣州中醫(yī)藥大學中醫(yī)骨傷科學國家重點學科實驗室;廣州中醫(yī)藥大學第一附屬醫(yī)院;
【基金】：廣東省自然基金項目(2016A030313641) 廣州中醫(yī)藥大學中醫(yī)骨傷科學國家重點學科開放基金資助(YB12) 2016年國家級大學生創(chuàng)新創(chuàng)業(yè)訓練計劃項目(201610572262)
【分類號】：R687.3;R580
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本文編號：1572464