本文關(guān)鍵詞： 非結(jié)構(gòu)性移植 皮膚年輕化 機(jī)械乳化處理法 Nanofat非結(jié)構(gòu)移植的動(dòng)物模型　出處：《山西醫(yī)科大學(xué)》2015年碩士論文　論文類型：學(xué)位論文

【摘要】：目的:第一部分觀察評(píng)價(jià)Nanofat移植在面部非結(jié)構(gòu)性移植中的臨床效果第二部分借鑒譚新穎等建立的可注射自體脂肪移植的動(dòng)物模型建立Nanofat非結(jié)構(gòu)性移植的動(dòng)物實(shí)驗(yàn)?zāi)Ｐ汀７椒?第一部分2014年9月至2014年12月,收集10例自愿來(lái)我院進(jìn)行脂肪移植治療女性患者,其中面頰部皮膚老化1例,眼周皮膚老化5例,額部皮膚老化2例,瘢痕2例。常規(guī)吸脂術(shù)獲取脂肪,機(jī)械乳化后留Nanofat,采用27號(hào)針頭真皮深層注射,直到皮膚顏色發(fā)生變化為止,注射后按療程定期來(lái)我院隨訪拍照及接受后續(xù)治療。第二部分從6只新西蘭家兔背部肩胛間區(qū)或腹股溝區(qū)獲取脂肪組織,取部分脂肪顆粒經(jīng)過(guò)機(jī)械乳化處理后作為實(shí)驗(yàn)組,移植到兔的右耳移植區(qū),未經(jīng)過(guò)處理的為對(duì)照組移植到兔左耳移植區(qū)。術(shù)后當(dāng)日,1月,2月對(duì)兩組脂肪成活率及對(duì)移植區(qū)域皮膚的影響。結(jié)果:第一部分有效9例,其中皮膚老化明顯改善7例,無(wú)效1例,無(wú)嚴(yán)重并發(fā)癥;隨訪期內(nèi)效果穩(wěn)定7例,再手術(shù)3例第二部分可注射脂肪的兔耳Nanofat非結(jié)構(gòu)性移植的動(dòng)物實(shí)驗(yàn)?zāi)Ｐ鸵子谟^察和活體測(cè)量,容易重復(fù)的優(yōu)點(diǎn)。結(jié)論:第一部分Nanofat移植有助于面部皮膚年輕化。第二部分Nanofat經(jīng)過(guò)機(jī)械乳化處理破壞了脂肪的組織結(jié)構(gòu)及失去細(xì)胞活性,影響了脂肪移植的成活率,但刺激了皮膚的修復(fù)與再生,為脂肪移植在非塑形領(lǐng)域提供了實(shí)驗(yàn)證據(jù)。
[Abstract]:Objective: the first part is to observe and evaluate the clinical effect of Nanofat transplantation in facial non-structural transplantation. The second part draws lessons from the animal model of injectable autogenous fat transplantation established by Tan Xin-et al to establish the animal experiment of Nanofat non-structural transplantation. Methods: part I, September 2014 to December 2014, A total of 10 female patients, including 1 case of skin aging in the cheek, 5 cases of skin aging around the eye, 2 cases of aging of the frontal skin, 2 cases of scar, and 2 cases of scar, were collected for the treatment of female patients with fat transplantation. After mechanical emulsification, Nanofat was retained and injected deep into the dermis of needle 27 until the skin color changed. In the second part, adipose tissue was obtained from the interscapular area or groin area of 6 New Zealand rabbits, and some fat particles were taken as experimental group after mechanical emulsification. Transplantation to the right ear of the rabbit and the control group to the left ear. The survival rate of fat and the effect on the skin of the two groups were observed on January and February. Results: the first part was effective in 9 cases. There were 7 cases of skin aging improved, 1 case of no serious complications, 7 cases of stable effect during the follow-up period, 3 cases of re-operation, 3 cases of the animal model of non-structural transplantation of fat injectable fat in rabbit ear, which was easy to observe and to measure in vivo. Conclusion: the first part of Nanofat graft is helpful for facial skin rejuvenation. The second part of Nanofat can destroy the tissue structure and lose cell activity of fat after mechanical emulsification, and affect the survival rate of fat transplantation. But it stimulates skin repair and regeneration, and provides experimental evidence for fat transplantation in the field of non-plastic.
【學(xué)位授予單位】：山西醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2015
【分類號(hào)】：R622.9

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