本文關(guān)鍵詞： 炎癥 術(shù)后認(rèn)知功能障礙 腫瘤 麻醉　出處：《中國癌癥雜志》2017年03期 　論文類型：期刊論文

【摘要】：術(shù)后認(rèn)知功能障礙(postoperative cognitive dysfunction,POCD)是患者在全身麻醉手術(shù)后出現(xiàn)的中樞神經(jīng)系統(tǒng)損害,其危險(xiǎn)因素及誘發(fā)因素非常復(fù)雜,具體機(jī)制尚不清楚。近年來,炎癥反應(yīng)在POCD發(fā)生、發(fā)展中的作用越來越受到重視,且有研究發(fā)現(xiàn)腫瘤引起的相關(guān)性炎癥也起了重要作用�，F(xiàn)以圍術(shù)期炎癥反應(yīng)作為切入點(diǎn),對其在POCD發(fā)生、發(fā)展中的作用及圍術(shù)期麻醉藥物及麻醉方法對炎癥反應(yīng)及POCD的影響作一綜述,以期深入了解POCD的發(fā)生機(jī)制,為腫瘤患者中POCD的高危人群麻醉藥物和麻醉方法的選擇提供理論依據(jù)和參考。
[Abstract]:Postoperative cognitive dysfunction. POCD is the central nervous system damage in patients after general anesthesia surgery. Its risk factors and inducing factors are very complex, the specific mechanism is not clear. In recent years, inflammatory reaction occurred in POCD. More and more attention has been paid to the role of development, and some studies have found that tumor-induced inflammation also plays an important role. The role of development and the effect of anesthetic drugs and methods on inflammatory response and POCD during perioperative period were reviewed in order to understand the pathogenesis of POCD. To provide theoretical basis and reference for the selection of anesthetic drugs and anesthetic methods in high risk population of POCD in cancer patients.
【作者單位】： 復(fù)旦大學(xué)附屬腫瘤醫(yī)院麻醉科 復(fù)旦大學(xué)上海醫(yī)學(xué)院腫瘤學(xué)系;
【分類號】：R614
【正文快照】： 術(shù)后認(rèn)知功能障礙(postoperative cognitivedysfunction,POCD)是指患者在手術(shù)或麻醉后出現(xiàn)精神錯(cuò)亂、焦慮、人格改變及記憶受損等,常見于接受胸科手術(shù)、重大手術(shù)、急癥手術(shù)后的老年患者,在中青年患者中的發(fā)病也時(shí)有報(bào)道[1]。一項(xiàng)國外多中心調(diào)查顯示,1 218例年齡大于60歲的老年

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