本文關(guān)鍵詞： 塞來昔布 重型顱腦損傷 神經(jīng)功能 臨床療效　出處：《中國醫(yī)院藥學(xué)雜志》2017年24期 　論文類型：期刊論文

【摘要】：目的:探討塞來昔布對(duì)重型顱腦損傷患者臨床療效及神經(jīng)功能的影響。方法:選取某院2014年1月-2016年12月重型顱腦損傷患者80例,并將其分為治療組和對(duì)照組。對(duì)照組進(jìn)行常規(guī)治療,治療組在對(duì)照組的基礎(chǔ)上給予塞來昔布治療。檢測(cè)2組患者血清TNF-α、IL-1β水平變化。2組患者治療7 d、14 d后行GCS評(píng)分,3個(gè)月后按GOS預(yù)后評(píng)分評(píng)定預(yù)后,治療前及治療3個(gè)月后Barthel指數(shù)評(píng)分,治療期間清醒時(shí)間及意識(shí)恢復(fù)清醒情況。結(jié)果:治療組患者治療后IL-1β、TNF-α水平顯著低于治療前(P0.05);治療組患者治療7 d、14 d后GCS評(píng)分均較治療前明顯增高(P0.05),治療組患者治療結(jié)束及隨訪結(jié)束時(shí)GOS評(píng)分均明顯高于對(duì)照組(P0.05);治療組患者治療3個(gè)月后Barthel評(píng)分相較對(duì)照組顯著提高(P0.05);治療組患者治療期間清醒時(shí)間明顯長(zhǎng)于對(duì)照組(P0.05);治療組患者治療期間意識(shí)恢復(fù)率明顯高于對(duì)照組(P0.05);治療組患者治愈率較對(duì)照組顯著升高(P0.05),治療組患者重殘率與病死率較對(duì)照組顯著降低(P0.05)。結(jié)論:塞來昔布可改善重型顱腦損傷患者預(yù)后及日常生活能力,促進(jìn)神經(jīng)功能恢復(fù)、降低病死率,臨床療效確切。
[Abstract]:Objective: to investigate the effect of celecoxib on the clinical efficacy and neurological function of patients with severe craniocerebral injury. Methods: 80 patients with severe craniocerebral injury from January 2014 to December 2016 in a hospital were selected. The patients in the treatment group were treated with celecoxib on the basis of the control group, and the serum TNF- 偽 was detected in the two groups. The changes of IL-1 尾 level in group 2 were evaluated by GCS score after 7 days and 14 days after treatment. The prognosis was evaluated by GOS prognostic score 3 months later. Barthel index score before treatment and 3 months after treatment, waking time and consciousness recovery during treatment. Results: IL-1 尾 in the treatment group after treatment. The level of TNF- 偽 was significantly lower than that before treatment (P 0.05). The GCS scores of the patients in the treatment group were significantly higher than those before treatment (P0.05). The GOS score at the end of treatment and follow-up in the treatment group was significantly higher than that in the control group (P 0.05). After 3 months of treatment, the Barthel score of the patients in the treatment group was significantly higher than that in the control group (P 0.05). The waking time of the patients in the treatment group was longer than that in the control group (P 0.05). The recovery rate of consciousness in the treatment group was significantly higher than that in the control group (P 0.05). The cure rate in the treatment group was significantly higher than that in the control group (P0.05). Conclusion: celecoxib can improve the prognosis and daily life ability of patients with severe craniocerebral injury and promote the recovery of nerve function. To reduce the mortality rate, the clinical curative effect is definite.
【作者單位】： 河北醫(yī)科大學(xué)附屬邢臺(tái)市人民醫(yī)院神經(jīng)外科;邢臺(tái)醫(yī)學(xué)高等�？茖W(xué)校藥學(xué)系;
【基金】：河北省自然科學(xué)基金項(xiàng)目(編號(hào):C2004000689) 河北省博士基金項(xiàng)目(編號(hào):05547008D-4) 河北省科學(xué)技術(shù)與社會(huì)發(fā)展計(jì)劃項(xiàng)目(編號(hào):04276135)
【分類號(hào)】：R651.15
【正文快照】： 顱腦外傷是神經(jīng)外科常見一種急危重癥,顱腦外傷的患病率占全身外傷性疾病的10%~15%,其中重型顱腦損傷(severe traumatic brain injury,sT-BI)病死率可高達(dá)30%~58%,其以病情重、病情復(fù)雜多變、并發(fā)癥多、療效差、治療難度大、致殘率和致死率高為特點(diǎn)[1]。常規(guī)治療方法效果欠佳,

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