醒腦靜注射液聯(lián)合高壓氧對重度顱腦損傷患者神經(jīng)功能恢復(fù)的影響
本文關(guān)鍵詞: 醒腦靜注射液 高壓氧 重癥顱腦損傷 神經(jīng)功能 出處:《中藥藥理與臨床》2017年02期 論文類型:期刊論文
【摘要】:目的:觀察醒腦靜注射液聯(lián)合高壓氧對重度顱腦損傷患者神經(jīng)功能恢復(fù)的影響。方法:2014年10月~2016年9月我院神經(jīng)外科收治的68例重癥顱腦損傷患者,所有患者均常規(guī)治療基礎(chǔ)上使用高壓氧治療,其中34例在以上治療基礎(chǔ)上另外加用醒腦靜注射液。觀察兩組患者治療后神經(jīng)功能的恢復(fù)情況。結(jié)果:治療一個月后,觀察組血清ET-1、S100B和NPY水平分別為(50.58±8.79ng/L、0.41±0.10μg/L、74.5±11.4ng/L),均明顯低于對照組(63.82±9.94ng/L、0.60±0.15μg/L、93.7±12.0ng/L)。治療3個月后,觀察組MMSE、NIHSS評分和記憶商值分別為(27.26±2.19分、15.89±1.49分、96.81±4.15),均明顯優(yōu)于對照組(23.85±2.05分、20.14±1.53分、85.99±3.96)。治療3個月后,對照組有2例患者死亡,觀察組無死亡患者,觀察組預(yù)后良好(IV+V)比例為50.00%,明顯高于對照組26.47%。(4)對照組患者治療期間發(fā)生20例(58.82%)肺部感染,明顯高于觀察組11例(32.35%)。結(jié)論:在高壓氧治療重度顱腦損傷患者基礎(chǔ)上,醒腦靜注射液可提高患者神經(jīng)功能恢復(fù)程度,并減少感染的發(fā)生。
[Abstract]:Objective: to observe the effect of Xingnaojing injection combined with hyperbaric oxygen on the recovery of nerve function in patients with severe craniocerebral injury. From October 2014 to September 2016, 68 cases of severe craniocerebral injury were treated in our hospital. All patients were treated with hyperbaric oxygen on the basis of routine therapy. 34 cases were treated with Xingnaojing injection on the basis of above treatment. The recovery of nerve function was observed in two groups. Results: one month after treatment, serum ET-1 was observed in the observation group. The levels of S100B and NPY were 50.58 鹵8.79ng / L 0.41 鹵0.10 渭 g / L respectively 74.5 鹵11.4ng / L). These results were significantly lower than those in the control group (63.82 鹵9.94 ng / L, 0.60 鹵0.15 渭 g / L, 93.7 鹵12.0 ng / L). After 3 months of treatment, MMSE was observed in the observation group. The scores of NIHSS and memory quotient were 27.26 鹵2.19, 15.89 鹵1.49 and 96.81 鹵4.15, respectively. It was significantly better than the control group (23.85 鹵2.05, 20.14 鹵1.53, 85.99 鹵3.96). After 3 months of treatment, 2 patients in the control group died. There was no death in the observation group, and the ratio of good prognosis in the observation group was 50.00%. It was significantly higher than that in the control group (26.47 vs 26.47) the patients in the control group had 20 cases of lung infection during the treatment period. Conclusion: on the basis of hyperbaric oxygen treatment for patients with severe craniocerebral injury, Xingnaojing injection can improve the degree of recovery of nerve function and reduce the incidence of infection in patients with severe craniocerebral injury.
【作者單位】: 南充市高坪區(qū)人民醫(yī)院;川北醫(yī)學(xué)院附院;
【分類號】:R651.15
【正文快照】: 重癥顱腦損傷是顱腦損傷分級最高的一種,多數(shù)患者腦組織存在嚴(yán)重?fù)p傷,部分患者昏迷時間可達24小時以上,預(yù)后不良。顱腦損傷后前期可能僅部分腦實質(zhì)受損,但隨著時間進展,患者可繼發(fā)多種腦實質(zhì)損害,以缺血缺氧或血腫壓迫等為主的繼發(fā)損害將進一步加重患者病情[1]。目前尚無針對
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