本文關(guān)鍵詞： 谷氨酰胺 顱腦損傷 二胺氧化酶 D-乳酸　出處：《安徽醫(yī)學(xué)》2016年11期 　論文類型：期刊論文

【摘要】：目的探討不同劑量谷氨酰胺腸內(nèi)營養(yǎng)對(duì)重度顱腦損傷患者血漿二胺氧化酶(DAO)和D-乳酸的影響。方法將安徽省立醫(yī)院南區(qū)2015年2月至2015年12月神經(jīng)外科住院的60例重度顱腦損傷患者以完全隨機(jī)化法分成3組:不含谷氨酰胺腸內(nèi)營養(yǎng)組(C組),低劑量0.3 g/(kg·d)谷氨酰胺腸內(nèi)營養(yǎng)組(L組),高劑量0.6 g/(kg·d)谷氨酰胺腸內(nèi)營養(yǎng)組(H組),每組20例。于腸內(nèi)營養(yǎng)支持的第1天、第8天、第15天晨空腹采血,檢測(cè)血漿DAO及D-乳酸水平,并比較其變化。結(jié)果 3組患者第1天血漿DAO及D-乳酸水平變化不明顯,差異無統(tǒng)計(jì)學(xué)意義(P0.05)。在第8天、第15天,L組和H組患者血漿DAO及D-乳酸水平低于C組,差異均有統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論添加谷氨酰胺腸內(nèi)營養(yǎng)有助于改善重度顱腦損傷患者的腸黏膜功能,且隨著谷氨酰胺劑量增加,保護(hù)作用加強(qiáng)。
[Abstract]:Objective to investigate the effects of different doses of glutamine enteral nutrition on plasma diamine oxidase (diamine oxidase) in patients with severe craniocerebral injury. Methods from February 2015 to December 2015, 60 patients with severe craniocerebral injury in the Southern District of Anhui Provincial Hospital were randomly divided into 3 groups:. No glutamine enteral nutrition group (. Group C). Low dose 0.3 g / kg / d) glutamine enteral nutrition group (group L) and high dose group (0.6 g / kg / d) glutamine enteral nutrition group (group H). Fasting blood samples were collected from 20 patients in each group on day 1, day 8 and day 15 of enteral nutrition support. Plasma levels of DAO and D-lactic acid were measured. Results there was no significant change in plasma DAO and D-lactic acid levels in the three groups on the first day, but there was no significant difference (P 0.05). On the 8th day and 15th day, there was no significant difference in plasma DAO and D-lactic acid levels in the three groups. The plasma levels of DAO and D-lactic acid in group L and group H were lower than those in group C. Conclusion addition of glutamine enteral nutrition can improve the intestinal mucosal function in patients with severe craniocerebral injury, and the protective effect is enhanced with the increase of glutamine dosage.
【作者單位】： 安徽省立醫(yī)院南區(qū)營養(yǎng)科;
【基金】：安徽省科技廳年度重點(diǎn)項(xiàng)目(項(xiàng)目編號(hào):12070403055)
【分類號(hào)】：R651.15;R459.3
【正文快照】： 重度顱腦損傷患者具有病情復(fù)雜,兇險(xiǎn)多變,病死率高和后遺癥嚴(yán)重等特點(diǎn)[1],占顱腦損傷的13%~21%,這類患者常出現(xiàn)腸黏膜通透性增加,細(xì)菌及內(nèi)毒素移位,導(dǎo)致膿毒血癥、多器官功能障礙綜合征等,嚴(yán)重影響患者預(yù)后[2]。因此,患者都需要營養(yǎng)支持促進(jìn)機(jī)體各臟器功能恢復(fù)。研究表明,谷氨

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