發(fā)布時間：2018-01-14 05:27

  本文關鍵詞：腦脊液分流術治療特發(fā)性顱內(nèi)壓增高癥的薈萃分析　出處：《吉林大學》2016年碩士論文　論文類型：學位論文

  更多相關文章： 特發(fā)性顱內(nèi)壓增高癥 良性顱內(nèi)壓增高癥 腦假瘤 腦室-腹腔分流術 腰大池-腹腔分流術 薈萃分析

【摘要】：背景和目的:腦脊液分流術常被用于治療頑固性特發(fā)性顱內(nèi)壓增高癥,但對其療效進行評價的研究十分缺乏。本研究是目前已知國內(nèi)僅有的、規(guī)模最大的對現(xiàn)有腦室-腹腔分流術或腰大池-腹腔分流術的相關文獻進行的薈萃分析。材料與方法:檢索1988至2014年所有同行評議雜志上發(fā)表的腦脊液分流術治療特發(fā)性顱內(nèi)壓增高癥的文獻,提取數(shù)據(jù)繪制表格,試圖通過對定性資的率進行χ2檢驗揭示腦脊液分流術治療特發(fā)性顱內(nèi)壓增高癥的普遍規(guī)律。結果:納入435例,術后54%視力改善、80%頭痛緩解、70%視乳頭水腫消除,43%需再次手術。大小并發(fā)癥發(fā)生率分別為7.6%和32.9%。頭痛、視乳頭水腫和視力下降的緩解率,分流失敗和術后低顱壓的發(fā)生率的χ2檢驗有顯著性意義,而再次手術率和分流管阻塞的發(fā)生率等的χ2檢驗則為陰性結果。結論:盡管存在著巨大的局限性,本研究初步揭示了腦脊液分流術不同術式治療特發(fā)性顱內(nèi)壓增高癥療效和并發(fā)癥的異同,而有關觀點的確證則有待于隨機對照試驗或有對照的觀察性研究的實行。
[Abstract]:Background and objective: cerebrospinal fluid shunt (CSF shunt) is often used to treat intractable idiopathic intracranial hypertension, but there is very little research to evaluate its curative effect. Largest meta-analysis of available literature on ventriculoperitoneal shunt or lumbar cisternoceliac shunt. Materials and methods:. To search the literature published in all peer-reviewed journals from 1988 to 2014 on the treatment of idiopathic intracranial hypertension with cerebrospinal fluid shunt. The data were drawn out and the 蠂 2 test was used to reveal the general rule of cerebrospinal fluid shunt in the treatment of idiopathic intracranial hypertension. Results: 54% cases of postoperative visual acuity were improved. 80% 70% of headache relief and 43% of the elimination of papillary edema required reoperation. The incidence of complications was 7.6% and 32.9.The remission rate of headache, papillary edema and visual acuity decreased. The 蠂 2 test of shunt failure and postoperative low intracranial pressure was significant, but the rate of reoperation and the incidence of shunt obstruction were negative. Conclusion: although there are great limitations. This study preliminarily revealed the similarities and differences of the effects and complications of cerebrospinal fluid shunt in the treatment of idiopathic intracranial hypertension. The corroboration of the views is to be carried out in randomized controlled trials or controlled observational studies.
【學位授予單位】：吉林大學
【學位級別】：碩士
【學位授予年份】：2016
【分類號】：R651.1

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本文編號：1422236