【摘要】：背景:目前有文獻報道了一些用來研究創(chuàng)傷的儀器設備,但是鑒于這些設備自身適用范圍有限,不利于創(chuàng)傷動物模型的建立。目的:研制一種多功能動物撞擊系統(tǒng)并評估其初步使用效果,為動物實驗創(chuàng)傷建模及基礎研究提供支撐。方法:多功能動物撞擊系統(tǒng)基于儲能換能裝置、簡便式多功能撞擊裝置、撞擊參數(shù)測量裝置等三大部件的原理設計,并對其有效性和穩(wěn)定性檢驗。采用撞擊儀預設定不同撞擊參數(shù)(200,300,400,500 k Pa)并選擇5 cm2撞擊頭對大鼠胸、腹部不同部位器官實施閉合撞擊實驗并立即記錄撞擊力數(shù)據(jù)。各部位不同撞擊參數(shù)下隨機選擇3只大鼠實行撞擊操作,隨后處死大鼠以解剖觀察。結果與結論:(1)成功地研制出該多功能撞擊儀,其撞擊應力峰值連續(xù)可調(diào)節(jié)且量程在0-200 kg,壓縮和擠壓應力連續(xù)可調(diào)節(jié)且量程在0-100 kg;(2)動物實驗表明儀器能夠造成大鼠肺、肝、脾等器官不同程度的組織損傷,驗證了該儀器具有良好的有效性(P0.05)和可重復性(P0.05);(3)結果說明,撞擊儀操作簡單,撞擊方式多樣,撞擊參數(shù)可被實時記錄;經(jīng)過調(diào)試和動物實驗,效果顯著且性能穩(wěn)定,可對不同實驗動物形成不同強度和方式的創(chuàng)傷。適用于撞擊傷的建模和有關基礎研究。
[Abstract]:Background: some instruments used to study trauma have been reported, but due to their limited scope of application, it is not conducive to the establishment of animal models of trauma. Aim: to develop a multifunctional animal impact system and evaluate its preliminary application effect, and provide support for animal experimental trauma modeling and basic research. Methods: the multifunctional animal impact system was designed based on the principle of energy transfer device, simple multi-function impact device and impact parameter measuring device, and its validity and stability were tested. Different impact parameters (200300400500 k Pa) were pre-set by impactor (200300400500 k Pa) and 5 cm2 impact head was selected to conduct closed impact test on different parts of the chest and abdomen of rats and to record the impact force data immediately. Under different impact parameters, 3 rats were randomly selected for impact operation, and then killed for anatomic observation. Results and conclusions: (1) the multifunctional impactor has been successfully developed. The impact stress peak value is continuously adjustable, the range is 0-200 kg, compression, the extrusion stress is continuously adjustable and the measuring range is 0-100 kg;. (2) Animal experiments show that the instrument can cause lung, liver, spleen and other organs of the rats to different degrees of tissue damage, verified that the instrument has a good effectiveness (P0.05) and repeatability (P0.05); (3) the results show that the impact instrument is simple in operation, various in impact mode, and the impact parameters can be recorded in real time. After debugging and animal experiments, the effect is remarkable and the performance is stable, and the trauma of different intensity and mode can be caused to different experimental animals. Applicable to impact injury modeling and related basic research.
【作者單位】： 解放軍成都軍區(qū)總醫(yī)院全軍普外中心;
【基金】：國家自然科學基金(81001695) 四川省科技廳應用基礎研究課題(2013JY0046)~~
【分類號】：R318.6

【參考文獻】

相關期刊論文 前10條

1 符鋒;趙明亮;李曉紅;陳，

本文編號：2344686