本文選題：視覺假體 + MEMS技術(shù)��； 參考：《上海交通大學(xué)》2012年碩士論文

【摘要】：通過植入式神經(jīng)微電極對人體的特定部位施加電刺激,能夠治療傳統(tǒng)藥物或手術(shù)無法治愈的神經(jīng)損傷性疾病,例如帕金森、癲癇、癱瘓、肌張力異常、老年癡呆、大小便失禁、心臟起搏異常、耳聾以及失明等。目前,視覺假體已經(jīng)成為神經(jīng)功能修復(fù)領(lǐng)域新的研究熱點。多通道神經(jīng)刺激微電極陣列作為視覺假體的一部分,直接與視覺神經(jīng)組織相接觸,是實現(xiàn)視覺功能修復(fù)的關(guān)鍵部件。隨著微機電系統(tǒng)(Micro-Electro-Mechanical System, MEMS)技術(shù)的不斷發(fā)展,多通道MEMS神經(jīng)刺激微電極陣列研究受到國內(nèi)外廣泛關(guān)注。 本文主要研究內(nèi)容包括:(1)基于MEMS技術(shù),研制可植入到脈絡(luò)膜上腔的柔性薄膜刺激微電極陣列。微電極直徑為350μm,按照6×10排布,4個可選的回收電極排布在刺激電極周圍。采用制作工藝簡單、性能良好的光敏型聚酰亞胺(PI)作為微電極襯底材料,生物相容性及電化學(xué)性能良好的金屬鉑(Pt)作為電極材料。為了增加電極密度,提高刺激電極空間分辨率,我們采用雙層金屬制作工藝,并且通過增加鈦(Ti)金屬層和氧等離子表面轟擊來提高襯底與導(dǎo)電層的黏附性。(2)對研制的刺激微電極陣列進(jìn)行體外與在體評估。利用三電極自動阻抗測試分析平臺,對脈絡(luò)膜上腔柔性微電極陣列進(jìn)行電化學(xué)阻抗測試與分析。通過體外循環(huán)伏安法和瞬態(tài)電壓測試確定了微電極的電荷儲存能力和電荷注入能力。兔子在體動物電生理實驗表明,不同的刺激電極誘發(fā)的視皮層最大響應(yīng)區(qū)域的位置不同。體外與在體實驗結(jié)果表明該脈絡(luò)膜上腔微電極陣列能夠?qū)崿F(xiàn)在體可靠工作。
[Abstract]:Electrical stimulation of specific parts of the body by implanting neural microelectrodes can treat neurological disorders that cannot be cured by traditional drugs or surgery, such as Parkinson's, epilepsy, paralysis, muscular dystonia, Alzheimer's disease, incontinence. Abnormal cardiac pacing, deafness and blindness. At present, visual prosthesis has become a new research hotspot in the field of nerve function restoration. As a part of visual prosthesis, multi-channel nerve stimulation microelectrode array is directly in contact with visual nerve tissue and is the key component of visual functional restoration. With the development of MEMS Micro-Electro-Mechanical system (MEMSS) technology, the research of multi-channel MEMS neural stimulation microelectrode array has been paid more and more attention at home and abroad. The main contents of this thesis are as follows: (1) based on MEMS technology, a flexible thin-film stimulated microelectrode array can be implanted into the suprachoroidal cavity. The diameter of the microelectrode is 350 渭 m. The microelectrode is arranged according to 6 脳 10 arrangement and 4 alternative recovery electrodes are arranged around the stimulation electrode. The Guang Min type polyimide (Pi) with simple fabrication process and good biocompatibility and electrochemical performance was used as the substrate material of the microelectrode and the platinum (Pt) with good biocompatibility and electrochemical performance was used as the electrode material. In order to increase the density of the electrode and improve the spatial resolution of the stimulant electrode, we adopt a double-layer metal fabrication process. The adhesion between substrate and conductive layer was improved by adding Ti (Ti) metal layer and oxygen plasma surface bombardment to evaluate the microelectrode array in vitro and in vivo. The electrochemical impedance measurement and analysis of flexible microelectrode arrays in the suprachoroidal cavity were carried out using a three electrode automatic impedance measurement platform. The charge storage capacity and charge injection capacity of the microelectrode were determined by cardiopulmonary bypass voltammetry and transient voltage measurement. The electrophysiological experiments of rabbits in vivo showed that the position of the maximum response region of the visual cortex induced by different stimulation electrodes was different. The results of in vitro and in vivo experiments show that the suprachoroidal microelectrode array can work reliably in vivo.
【學(xué)位授予單位】：上海交通大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2012
【分類號】：R318.1

【共引文獻(xiàn)】

相關(guān)碩士學(xué)位論文 前10條

1 史靜茹;仿真假體視覺下基于不規(guī)則光幻視陣列的物體識別研究[D];上海交通大學(xué);2011年

2 顧柳君;仿真假體視覺下基于運動檢測的運動物體識別研究[D];上海交通大學(xué);2012年

3 張偉峰;通用可配置生物電刺激芯片的設(shè)計[D];上海交通大學(xué);2011年

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5 李瑩輝;視覺假體神經(jīng)刺激微電極的研究[D];上海交通大學(xué);2008年

6 劉舒維;人造視網(wǎng)膜生物微電極陣列研究[D];上海交通大學(xué);2008年

7 凌舒;基于觸覺感知的仿真光幻視特性研究[D];上海交通大學(xué);2009年

8 邵軼彬;基于有限元分析方法的視覺假體微電極陣列的設(shè)計與測試[D];上海交通大學(xué);2009年

9 夏露;一種經(jīng)硬腦膜的視皮層電刺激裝置的設(shè)計與實驗研究[D];重慶大學(xué);2009年

10 陳巍;人工視覺用聚酰亞胺薄膜電極的生物相容性及電刺激對神經(jīng)膠質(zhì)細(xì)胞的影響[D];復(fù)旦大學(xué);2009年

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本文編號：2016254